Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/19475
Title: Identification of Loci Associated with Parasite Resistance in Australian Sheep
Contributor(s): al Kalaldeh, Mohammad  (author); Van Der Werf, Julius H  (author)orcid ; Gondro, Cedric  (author)orcid 
Publication Date: 2015
Open Access: Yes
Handle Link: https://hdl.handle.net/1959.11/19475
Open Access Link: http://www.aaabg.org/aaabghome/AAABG21papers/Kalaldeh21069.pdfOpen Access Link
Abstract: This study aimed to identify loci underlying variation in parasite resistance, as measured by worm egg count (WEC), in a large multi-breed sheep population using genome-wide association studies (GWAS) and regional heritability mapping (RHM) approaches. A total of 7153 animals with both genotype data and WEC phenotypes were included in this analysis. Strong evidence of association was observed on chromosome 2 by both approaches. However, RHM had a greater power to identify loci than GW AS analysis. RHM identified an additional region at the genomewide significance level on chromosome 6. This region was also previously found to be associated with mastitis resistance and facial eczema susceptibility in sheep, indicating that some pleiotropic effects are possibly affecting a wide range of sheep diseases. Three other regions on chromosome I, 3 and 24 reached the suggestive threshold.
Publication Type: Conference Publication
Conference Name: 21st Conference of the Association for the Advancement of Animal Breeding and Genetics, Lorne, Australia, 28th - 30th September, 2015
Conference Details: 21st Conference of the Association for the Advancement of Animal Breeding and Genetics, Lorne, Australia, 28th - 30th September, 2015
Source of Publication: Proceedings of the Twenty-first Conference of the Association for the Advancement of Animal Breeding and Genetics, p. 69-72
Publisher: AAABG: Association for the Advancement of Animal Breeding and Genetics
Place of Publication: Bundoora, Australia
Field of Research (FOR): 070201 Animal Breeding
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Other Links: http://www.aaabg.org/aaabghome/proceedings21.php
Series Name: Proceedings of the AAABG ... Conference
Series Number : 21
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