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|Title:||Design of reference populations for genomic selection in crossbreeding programs||Contributor(s):||van Grevenhof, Ilse E M (author); Van Der Werf, Julius H (author)||Publication Date:||2015||Open Access:||Yes||DOI:||10.1186/s12711-015-0104-x||Handle Link:||https://hdl.handle.net/1959.11/19459||Abstract:||'Background': In crossbreeding programs, genomic selection offers the opportunity to make efficient use of information on crossbred (CB) individuals in the selection of purebred (PB) candidates. In such programs, reference populations often contain genotyped PB animals, although the breeding objective is usually more focused on CB performance. The question is what would be the benefit of including a larger proportion of CB individuals in the reference population. 'Methods': In a deterministic simulation study, we evaluated the benefit of including various proportions of CB animals in a reference population for genomic selection of PB animals in a crossbreeding program. We used a pig breeding scheme with selection for a moderately heritable trait and a size of 6000 for the reference population. 'Results': Applying genomic selection to improve the performance of CB individuals, with a genetic correlation between PB and CB performance (rPC) of 0.7, selection accuracy of PB candidates increased from 0.49 to 0.52 if the reference population consisted of PB individuals, it increased to 0.55 if the reference population consisted of the same number of CB individuals, and to 0.60 if the size of the CB reference population was twice that of the reference population for each PB line. The advantage of using CB rather than PB individuals increased linearly with the proportion of CB individuals in the reference population. This advantage disappeared quickly if rPC was higher or if the breeding objective put some emphasis on PB performance. The benefit of adding CB individuals to an existing PB reference population was limited for high rPC. 'Conclusions': Using CB rather than PB individuals in a reference population for genomic selection can provide substantial advantages, but only when correlations between PB and CB performances are not high and PB performance is not part of the breeding objective.||Publication Type:||Journal Article||Source of Publication:||Genetics Selection Evolution, 47(14), p. 1-9||Publisher:||BioMed Central Ltd||Place of Publication:||United Kingdom||ISSN:||0999-193X
|Field of Research (FOR):||070201 Animal Breeding||Socio-Economic Outcome Codes:||830308 Pigs||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 43
|Appears in Collections:||Journal Article|
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