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https://hdl.handle.net/1959.11/19446
Title: | Effects of chronic infection with 'Trichostrongylus vitrinus' and immune suppression with corticosteroid on parasitological, immune and performance variables in crossbred meat lambs | Contributor(s): | Blackburn, Paul Jonathan (author); Carmichael, Ian (author); Walkden-Brown, Steve W (author) | Publication Date: | 2015 | DOI: | 10.1016/j.rvsc.2015.03.012 | Handle Link: | https://hdl.handle.net/1959.11/19446 | Abstract: | The effects of, and interactions between chronic 'Trichostrongylus vitrinus' infection and immune suppression with methylprednisolone were investigated for a period of 112 days in a grazed flock of 176 crossbred meat lambs. Worm egg count of non-immune-suppressed lambs increased rapidly from days 21 to 42 post-initial infection, and then steadily declined. Infection was associated with significantly decreased fat depth, eye muscle area and cold carcase weight, and increased circulating anti-'T. vitrinus' IgG and IgA. Immune suppression led to sustained increases in WEC, and significantly greater worm count, liver weight, fat depth and carcase dressing percentage, and significantly reduced IgG and IgA anti-'T. vitrinus' titres, lymphocyte counts, adrenal weight, eye muscle area and cold carcase weight. Both infection and immune suppression were associated with significant body weight reductions. Only 39% of reduced growth rate due to infection was attributable to the host immune response to 'T. vitrinus'. | Publication Type: | Journal Article | Source of Publication: | Research in Veterinary Science, v.100, p. 138-147 | Publisher: | Elsevier Ltd | Place of Publication: | United Kingdom | ISSN: | 1532-2661 0034-5288 |
Fields of Research (FoR) 2008: | 070705 Veterinary Immunology 070709 Veterinary Pathology |
Fields of Research (FoR) 2020: | 300906 Veterinary immunology 300910 Veterinary pathology |
Socio-Economic Objective (SEO) 2008: | 830310 Sheep - Meat | Socio-Economic Objective (SEO) 2020: | 100412 Sheep for meat | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Environmental and Rural Science |
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