Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/19296
Title: Effects of pre-procedural remote ischaemic pre-conditioning on the outcomes of elective percutaneous coronary intervention: A systematic review and meta-analysis
Contributor(s): King, Nicola (author); Dieberg, Gudrun  (author)orcid ; Smart, Neil  (author)orcid 
Publication Date: 2016
Open Access: Yes
DOI: 10.1016/j.ctrsc.2016.06.001Open Access Link
Handle Link: https://hdl.handle.net/1959.11/19296
Abstract: 'Objectives': Trials of remote ischemic pre-conditioning (RIPC) have suggested this intervention reduces complications of percutaneous coronary intervention and coronary by-pass surgery. The aims of this work were to (i) conduct a systematic review and meta-analysis of the effects of RIPC on cardiac and renal damage in patients undertaking elective percutaneous coronary intervention (PCI); (ii) summarize the results in an evidence based clinical context. 'Methods': We conducted a systematic search of published randomized controlled trials of RIPC for elective PCI up until May 1st, 2015. Studies of peri- or post-ischemic conditioning or emergency PCI were excluded. 'Results': Nine studies, totalling 1253 patients were included. Compared to control, RIPC groups exhibited reduced peri-procedural myocardial infarction (MI) Odds Ratio (OR) 0.72 (95% CI 0.54 to 0.97, p=0.03); ST-segment deviation OR 0.42 (95% CI 0.28 to 0.63, p b 0.0001); major adverse cardiac events (MACE) OR 0.41 (95% CI 0.21 to 0.84, p = 0.01); and acute kidney injury (AKI) OR 0.47 (95% CI 0.26 to 0.86, p = 0.01), but not mortality OR 1.00 (95% CI 0.27 to 3.73, p = 1.00). 'Conclusions': RIPC is likely to prevent major adverse cardiac and renal events in patients undertaking elective PCI.
Publication Type: Journal Article
Source of Publication: Clinical Trials and Regulatory Science in Cardiology, v.21, p. 1-6
Publisher: Elsevier BV
Place of Publication: Netherlands
ISSN: 2405-5875
Fields of Research (FoR) 2008: 110201 Cardiology (incl. Cardiovascular Diseases)
Fields of Research (FoR) 2020: 320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objective (SEO) 2008: 920103 Cardiovascular System and Diseases
Socio-Economic Objective (SEO) 2020: 200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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