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https://hdl.handle.net/1959.11/18874
Title: | Autoantibodies are not predictive markers for the development of depressive symptoms in a population-based cohort of older adults | Contributor(s): | Iseme, R A (author); McEvoy, M (author); Kelly, B (author); Agnew, Linda (author) ; Attia, J (author); Walker, F R (author); Oldmeadow, C (author); Boyle, M (author) | Publication Date: | 2015 | DOI: | 10.1016/j.eurpsy.2015.06.006 | Handle Link: | https://hdl.handle.net/1959.11/18874 | Abstract: | Background: Autoantibodies have been implicated in the etiologic pathway of depressive disorders. Here, we determine the association between the presence of a panel of autoantibodies at baseline and change in depression symptom score over 5-year follow-up in a cohort of healthy elderly Australians. Methods: Serum samples from 2049 randomly selected subjects enrolled in the Hunter Community Study (HCS) aged 55-85 years were assayed for a range of autoimmune markers (anti-nuclear autoantibodies, extractable nuclear antigen autoantibodies, anti-neutrophil cytoplasmic autoantibodies, thyroid peroxidase autoantibodies, tissue transglutaminase autoantibodies, anti-cardiolipin autoantibodies, rheumatoid factor and cyclic citrullinated peptide autoantibodies) at baseline. Depression symptom score was assessed using the Centre for Epidemiological Study (CES-D) scale at baseline and 5 years later. Results: Autoantibody prevalence varied amongst our sample with ANA being the most prevalent; positive in 16% and borderline in 36% of study population. No evidence for a relationship was found between change in CES-D score over time and any autoimmune marker. Statins and high cholesterol were significantly associated with change in CES-D score over time in univariate analysis; however, these were probably confounded since they failed to remain significant following multivariable analysis. Conclusions: Autoantibodies were not associated with change in CES-D score over time. These findings point to an absence of autoimmune mechanisms in the general population or in moderate cases of depression. | Publication Type: | Journal Article | Source of Publication: | European Psychiatry, 30(6), p. 694-700 | Publisher: | Elsevier Masson | Place of Publication: | France | ISSN: | 1778-3585 0924-9338 |
Fields of Research (FoR) 2008: | 110903 Central Nervous System | Fields of Research (FoR) 2020: | 320903 Central nervous system | Socio-Economic Objective (SEO) 2008: | 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Socio-Economic Objective (SEO) 2020: | 200199 Clinical health not elsewhere classified | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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