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https://hdl.handle.net/1959.11/18829
Title: | Remote ischaemic pre-conditioning does not affect clinical outcomes following coronary Artery bypass grafting: A systematic review and meta-analysis | Contributor(s): | King, Nicola (author); Dieberg, Gudrun (author) ; Smart, Neil (author) | Publication Date: | 2016 | Open Access: | Yes | DOI: | 10.1016/j.ctrsc.2016.03.001 | Handle Link: | https://hdl.handle.net/1959.11/18829 | Abstract: | Background: Trials of remote ischemic pre-conditioning (RIPC) have suggested this intervention reduces complications of angioplasty and coronary artery by-pass grafting (CABG). The aim of this work was to conduct a systematic review and meta-analysis of the effects of RIPC on mortality and myocardial damage in patients undertaking coronary artery bypass grafting with/without valve surgery. Methods: A systematic review and subsequent meta-analysis of randomized controlled trials of RIPC versus usual care or sham RIPC was performed. Results: Eighteen studies, totalling 4551 participants were analysed. RIPC reduced post troponin release as indicated by area under the curve at 72 h (µg.⁻¹) Mean Difference (MD) - 3.72 (95% CI - 3.92 to - 3.53, p < 0.00001). However there was no significant difference between RIPC and control when mortality odds ratio (OR) 1.27 (95% CI 0.87 to 1.86, p = 0.22); the incidence of new onset atrial fibrillation OR 0.82 (95% CI 0.67 to 1.01, p = 0.06); inotropic support OR 1.27 (95% CI 0.84 to 1.91, p = 0.25); intensive care unit stay in days MD - 0.02 (95% CI - 0.12 to 0.07, p = 0.61); Hospital stay in days MD 0.18 (95% CI - 0.30 to 0.66, p = 0.47) and serum creatinine MD - 0.00 (95% CI - 0.07 to 0.07, p = 0.97) were compared. Conclusions: RIPC reduces does not confer any clinical benefit in patients undertaking CABG with/without valve surgery. | Publication Type: | Journal Article | Source of Publication: | Clinical Trials and Regulatory Science in Cardiology, v.17, p. 1-8 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 2405-5875 | Fields of Research (FoR) 2008: | 110201 Cardiology (incl. Cardiovascular Diseases) 111716 Preventive Medicine 111603 Systems Physiology |
Fields of Research (FoR) 2020: | 320101 Cardiology (incl. cardiovascular diseases) | Socio-Economic Objective (SEO) 2008: | 920103 Cardiovascular System and Diseases | Socio-Economic Objective (SEO) 2020: | 200101 Diagnosis of human diseases and conditions | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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