Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/18689
Title: | The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial | Contributor(s): | Hagstrom, Amanda (author)![]() |
Publication Date: | 2016 | DOI: | 10.1007/s10549-016-3688-0 | Handle Link: | https://hdl.handle.net/1959.11/18689 | Abstract: | The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors. | Publication Type: | Journal Article | Source of Publication: | Breast Cancer Research and Treatment, 155(3), p. 471-482 | Publisher: | Springer New York LLC | Place of Publication: | United States of America | ISSN: | 1573-7217 0167-6806 |
Fields of Research (FoR) 2008: | 110602 Exercise Physiology 110799 Immunology not elsewhere classified 111299 Oncology and Carcinogenesis not elsewhere classified |
Fields of Research (FoR) 2020: | 420702 Exercise physiology | Socio-Economic Objective (SEO) 2008: | 920102 Cancer and Related Disorders 970111 Expanding Knowledge in the Medical and Health Sciences |
Socio-Economic Objective (SEO) 2020: | 280103 Expanding knowledge in the biomedical and clinical science 280114 Expanding knowledge in Indigenous studies 280112 Expanding knowledge in the health sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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