Haqq, Liza; McFarlane, James; Dieberg, Gudrun; Smart, Neil

Author(s)

Haqq, Liza

McFarlane, James

Dieberg, Gudrun

Smart, Neil

Publication Date

2015

Abstract

Introduction: Polycystic ovarian syndrome (PCOS) affects 18-22% women of reproductive age. We conducted a systematic review and meta-analysis to quantify expected benefits of lifestyle (exercise and dietary) interventions on various clinical outcomes in PCOS. Methods: Potential studies were identified by conducting systematic search of PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane controlled trials registry (1966 to April 2013) using key concepts of PCOS, exercise, dietary and lifestyle interventions. Results: Significant improvements were seen in women who received lifestyle intervention vs. usual care, in body composition parameters of body mass index, mean difference (MD) = -0.12 kg.m⁻² (95% CI [-0.22, -0.03], p = .009), body mass MD = -3.42 kg (95% CI [-4.86, -1.99], p < .00001), waist circumference MD = -1.64 cm (95% CI [-2.09, -1.19], p < .00001), waist-hip ratio MD = -0.03 (95% CI [-0.05, -0.01], p = .0002), and body fat % MD = -1.71% (95% CI [-3.10, -0.32], p = .02). Insulin did not improve, MD = -1.21 pmol/L (95% CI [-3.06, -0.63], p = .20). Lipid profile did not improve, total cholesterol MD = -0.02 mmol/L (95% CI [-0.25, 0.21], p = .89). C-reactive protein was significantly lower, MD = -0.47 mmol/L (95% CI [-0.80, -0.15], p = .004). Significant improvements were also observed in cardiorespiratory fitness with exercise alone reducing resting heart rate, MD = -1.89 beats.min⁻¹ (95% CI [-2.90, -0.88], p = .0002), and peak VO₂, MD = 4.86 ml.kg⁻¹.min⁻¹ (95% CI [2.83, 6.88], p < .00001). Lifestyle therapy also improved, peak VO₂ MD = 5.09 ml.kg⁻¹.min⁻¹ (95% CI [3.13, 7.05], p < .00001). Conclusions: Our analyses suggest lifestyle intervention is optimal for improving body composition and cardiorespiratory fitness in women with PCOS.

Citation

International Journal of Sport Nutrition and Exercise Metabolism, 25(6), p. 533-540

ISSN

1543-2742

1526-484X

Link

https://hdl.handle.net/1959.11/18587

Publisher

Human Kinetics, Inc

Title

The Effect of Lifestyle Intervention on Body Composition, Glycaemic Control and Cardio-Respiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis

Type of document

Journal Article

Entity Type

Publication

Author(s)	Haqq, Liza McFarlane, James Dieberg, Gudrun Smart, Neil
Publication Date	2015
Abstract	Introduction: Polycystic ovarian syndrome (PCOS) affects 18-22% women of reproductive age. We conducted a systematic review and meta-analysis to quantify expected benefits of lifestyle (exercise and dietary) interventions on various clinical outcomes in PCOS. Methods: Potential studies were identified by conducting systematic search of PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane controlled trials registry (1966 to April 2013) using key concepts of PCOS, exercise, dietary and lifestyle interventions. Results: Significant improvements were seen in women who received lifestyle intervention vs. usual care, in body composition parameters of body mass index, mean difference (MD) = -0.12 kg.m⁻² (95% CI [-0.22, -0.03], p = .009), body mass MD = -3.42 kg (95% CI [-4.86, -1.99], p < .00001), waist circumference MD = -1.64 cm (95% CI [-2.09, -1.19], p < .00001), waist-hip ratio MD = -0.03 (95% CI [-0.05, -0.01], p = .0002), and body fat % MD = -1.71% (95% CI [-3.10, -0.32], p = .02). Insulin did not improve, MD = -1.21 pmol/L (95% CI [-3.06, -0.63], p = .20). Lipid profile did not improve, total cholesterol MD = -0.02 mmol/L (95% CI [-0.25, 0.21], p = .89). C-reactive protein was significantly lower, MD = -0.47 mmol/L (95% CI [-0.80, -0.15], p = .004). Significant improvements were also observed in cardiorespiratory fitness with exercise alone reducing resting heart rate, MD = -1.89 beats.min⁻¹ (95% CI [-2.90, -0.88], p = .0002), and peak VO₂, MD = 4.86 ml.kg⁻¹.min⁻¹ (95% CI [2.83, 6.88], p < .00001). Lifestyle therapy also improved, peak VO₂ MD = 5.09 ml.kg⁻¹.min⁻¹ (95% CI [3.13, 7.05], p < .00001). Conclusions: Our analyses suggest lifestyle intervention is optimal for improving body composition and cardiorespiratory fitness in women with PCOS.
Citation	International Journal of Sport Nutrition and Exercise Metabolism, 25(6), p. 533-540
ISSN	1543-2742 1526-484X
Link	https://hdl.handle.net/1959.11/18587
Publisher	Human Kinetics, Inc
Title	The Effect of Lifestyle Intervention on Body Composition, Glycaemic Control and Cardio-Respiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis
Type of document	Journal Article
Entity Type	Publication

The Effect of Lifestyle Intervention on Body Composition, Glycaemic Control and Cardio-Respiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis

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