Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/18587
Title: The Effect of Lifestyle Intervention on Body Composition, Glycaemic Control and Cardio-Respiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis
Contributor(s): Haqq, Liza  (author); McFarlane, James R (author)orcid ; Dieberg, Gudrun  (author)orcid ; Smart, Neil  (author)orcid 
Publication Date: 2015
Open Access: Yes
DOI: 10.1123/ijsnem.2013-0232
Handle Link: https://hdl.handle.net/1959.11/18587
Abstract: Introduction: Polycystic ovarian syndrome (PCOS) affects 18-22% women of reproductive age. We conducted a systematic review and meta-analysis to quantify expected benefits of lifestyle (exercise and dietary) interventions on various clinical outcomes in PCOS. Methods: Potential studies were identified by conducting systematic search of PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane controlled trials registry (1966 to April 2013) using key concepts of PCOS, exercise, dietary and lifestyle interventions. Results: Significant improvements were seen in women who received lifestyle intervention vs. usual care, in body composition parameters of body mass index, mean difference (MD) = -0.12 kg.m⁻² (95% CI [-0.22, -0.03], p = .009), body mass MD = -3.42 kg (95% CI [-4.86, -1.99], p < .00001), waist circumference MD = -1.64 cm (95% CI [-2.09, -1.19], p < .00001), waist-hip ratio MD = -0.03 (95% CI [-0.05, -0.01], p = .0002), and body fat % MD = -1.71% (95% CI [-3.10, -0.32], p = .02). Insulin did not improve, MD = -1.21 pmol/L (95% CI [-3.06, -0.63], p = .20). Lipid profile did not improve, total cholesterol MD = -0.02 mmol/L (95% CI [-0.25, 0.21], p = .89). C-reactive protein was significantly lower, MD = -0.47 mmol/L (95% CI [-0.80, -0.15], p = .004). Significant improvements were also observed in cardiorespiratory fitness with exercise alone reducing resting heart rate, MD = -1.89 beats.min⁻¹ (95% CI [-2.90, -0.88], p = .0002), and peak VO₂, MD = 4.86 ml.kg⁻¹.min⁻¹ (95% CI [2.83, 6.88], p < .00001). Lifestyle therapy also improved, peak VO₂ MD = 5.09 ml.kg⁻¹.min⁻¹ (95% CI [3.13, 7.05], p < .00001). Conclusions: Our analyses suggest lifestyle intervention is optimal for improving body composition and cardiorespiratory fitness in women with PCOS.
Publication Type: Journal Article
Source of Publication: International Journal of Sport Nutrition and Exercise Metabolism, 25(6), p. 533-540
Publisher: Human Kinetics Inc
Place of Publication: United States of America
ISSN: 1543-2742
1526-484X
Field of Research (FOR): 110306 Endocrinology
110602 Exercise Physiology
111404 Reproduction
Socio-Economic Outcome Codes: 920114 Reproductive System and Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Science and Technology

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