The Effect of Lifestyle Intervention on Body Composition, Glycaemic Control and Cardio-Respiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis

Title
The Effect of Lifestyle Intervention on Body Composition, Glycaemic Control and Cardio-Respiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis
Publication Date
2015
Author(s)
Haqq, Liza
McFarlane, James
( author )
OrcID: https://orcid.org/0000-0003-4429-5384
Email: jmcfarla@une.edu.au
UNE Id une-id:jmcfarla
Dieberg, Gudrun
( author )
OrcID: https://orcid.org/0000-0001-7191-182X
Email: gdieberg@une.edu.au
UNE Id une-id:gdieberg
Smart, Neil
( author )
OrcID: https://orcid.org/0000-0002-8290-6409
Email: nsmart2@une.edu.au
UNE Id une-id:nsmart2
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Human Kinetics, Inc
Place of publication
United States of America
DOI
10.1123/ijsnem.2013-0232
UNE publication id
une:18791
Abstract
Introduction: Polycystic ovarian syndrome (PCOS) affects 18-22% women of reproductive age. We conducted a systematic review and meta-analysis to quantify expected benefits of lifestyle (exercise and dietary) interventions on various clinical outcomes in PCOS. Methods: Potential studies were identified by conducting systematic search of PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane controlled trials registry (1966 to April 2013) using key concepts of PCOS, exercise, dietary and lifestyle interventions. Results: Significant improvements were seen in women who received lifestyle intervention vs. usual care, in body composition parameters of body mass index, mean difference (MD) = -0.12 kg.m⁻² (95% CI [-0.22, -0.03], p = .009), body mass MD = -3.42 kg (95% CI [-4.86, -1.99], p < .00001), waist circumference MD = -1.64 cm (95% CI [-2.09, -1.19], p < .00001), waist-hip ratio MD = -0.03 (95% CI [-0.05, -0.01], p = .0002), and body fat % MD = -1.71% (95% CI [-3.10, -0.32], p = .02). Insulin did not improve, MD = -1.21 pmol/L (95% CI [-3.06, -0.63], p = .20). Lipid profile did not improve, total cholesterol MD = -0.02 mmol/L (95% CI [-0.25, 0.21], p = .89). C-reactive protein was significantly lower, MD = -0.47 mmol/L (95% CI [-0.80, -0.15], p = .004). Significant improvements were also observed in cardiorespiratory fitness with exercise alone reducing resting heart rate, MD = -1.89 beats.min⁻¹ (95% CI [-2.90, -0.88], p = .0002), and peak VO₂, MD = 4.86 ml.kg⁻¹.min⁻¹ (95% CI [2.83, 6.88], p < .00001). Lifestyle therapy also improved, peak VO₂ MD = 5.09 ml.kg⁻¹.min⁻¹ (95% CI [3.13, 7.05], p < .00001). Conclusions: Our analyses suggest lifestyle intervention is optimal for improving body composition and cardiorespiratory fitness in women with PCOS.
Link
Citation
International Journal of Sport Nutrition and Exercise Metabolism, 25(6), p. 533-540
ISSN
1543-2742
1526-484X
Start page
533
End page
540

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