Profilin-1 mediated cell-cycle arrest: searching for drug targets

Title
Profilin-1 mediated cell-cycle arrest: searching for drug targets
Publication Date
2015
Author(s)
Moens, Pierre
( author )
OrcID: https://orcid.org/0000-0003-3121-5306
Email: pmoens@une.edu.au
UNE Id une-id:pmoens
Coumans-Moens, Joelle
( author )
OrcID: https://orcid.org/0000-0001-6642-5202
Email: jmoensco@une.edu.au
UNE Id une-id:jmoensco
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Taylor & Francis Inc
Place of publication
United States of America
DOI
10.1080/15384101.2015.1086204
UNE publication id
une:18738
Abstract
Proliferation, resistance to apoptosis and migration are hallmarks of cancer cells and the main focus of targeted therapies in recent years. The rationale behind targeted therapies is to attack cancer cells without damaging or affecting healthy cells consequently reducing the severe side effect associated with standard chemotherapy. Therefore, a thorough understanding of the underlying cellular pathways leading to proliferation, cell death and metastasis and their alterations in malignant cells is of most importance. In the last 20 years, profilin 1 (Pfn1), a small ubiquitously expressed cytoskeletal protein has been the subject of increased interest as a potential therapeutic target in the fight against several types of cancers including breast, pancreatic, hepatic and bladder cancer. Pfn1 is known to have a reduced expression in these cancer types and increased expression of Pfn1 in some breast cancer cells reduces the tumorigenicity of the cells. It has recently been shown that overexpression of Pfn1 in the human breast cancer cell line MDA-MB 231 induces alterations of the expression of a range of proteins involved in cell proliferation, motility and survival.1 However, the mechanisms underlying the reduced motility and proliferation and increased apoptosis obeserved in these MDA-MB 231 cells are still largely unknown.
Link
Citation
Cell Cycle, 14(23), p. 3669-3670
ISSN
1538-4101
1551-4005
Start page
3669
End page
3670

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