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Title: Profilin-1 mediated cell-cycle arrest: searching for drug targets
Contributor(s): Moens, Pierre  (author)orcid ; Coumans-Moens, Joelle  (author)orcid 
Publication Date: 2015
Open Access: Yes
DOI: 10.1080/15384101.2015.1086204Open Access Link
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Abstract: Proliferation, resistance to apoptosis and migration are hallmarks of cancer cells and the main focus of targeted therapies in recent years. The rationale behind targeted therapies is to attack cancer cells without damaging or affecting healthy cells consequently reducing the severe side effect associated with standard chemotherapy. Therefore, a thorough understanding of the underlying cellular pathways leading to proliferation, cell death and metastasis and their alterations in malignant cells is of most importance. In the last 20 years, profilin 1 (Pfn1), a small ubiquitously expressed cytoskeletal protein has been the subject of increased interest as a potential therapeutic target in the fight against several types of cancers including breast, pancreatic, hepatic and bladder cancer. Pfn1 is known to have a reduced expression in these cancer types and increased expression of Pfn1 in some breast cancer cells reduces the tumorigenicity of the cells. It has recently been shown that overexpression of Pfn1 in the human breast cancer cell line MDA-MB 231 induces alterations of the expression of a range of proteins involved in cell proliferation, motility and survival.1 However, the mechanisms underlying the reduced motility and proliferation and increased apoptosis obeserved in these MDA-MB 231 cells are still largely unknown.
Publication Type: Journal Article
Source of Publication: Cell Cycle, 14(23), p. 3669-3670
Publisher: Taylor & Francis Inc
Place of Publication: United States of America
ISSN: 1538-4101
Field of Research (FOR): 111201 Cancer Cell Biology
060103 Cell Development, Proliferation and Death
111601 Cell Physiology
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Rural Medicine
School of Science and Technology

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