Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/18521
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPalanisamy, Suresh K Aen
dc.contributor.authorSharpley, Christopher Fen
dc.contributor.authorCoumans, Joelle V Fen
dc.contributor.authorMoens, Pierreen
dc.contributor.authorHerrid, Murenen
dc.contributor.authorSmart, Neil Aen
dc.contributor.authorMcFarlane, James Ren
dc.date.accessioned2016-02-04T12:37:00Z-
dc.date.issued2015-
dc.identifier.citationAdvances in Mental Health, 13(1), p. 7-17en
dc.identifier.issn1837-4905en
dc.identifier.issn1838-7357en
dc.identifier.urihttps://hdl.handle.net/1959.11/18521-
dc.description.abstractStress is clearly associated with the quality of life and many diseases, including mental disorders, with cortisol being a recognized biomarker for stress. Polymorphisms of the serotonin transporter gene (5-HTT), which results in long and short forms, have been reported to be associated with depression among major depressive disorder (MDD) patients. We have previously shown that 5-HTTLPR and waking cortisol do not predict depression in a general population sample, however, psychological resilience is a defence against depression. Reelin is an emerging biomarker for psychological resilience that plays an active role in neuronal migration. It is responsible for cytoarchitechtonic pattern formation in brain and modulates the migration of newly generated postmitotic neurons from the ventricular zone. In mice, overexpression of reelin in the hippocampus has anti-depressant activity by increasing neurogenesis and improving learning. A number of single nucleotide polymorphisms (SNPs), methylation of the promoter and coding region of the reelin (RELN) gene have been identified which affect the level of RELN mRNA and protein expression. Thus RELN is a potential candidate as a biomarker of psychological resilience and we have developed a rapid high-resolution melting (HRM) PCR analysis technique for the RELN SNPs and loci using gDNA isolated from buccal cells to test this hypothesis.en
dc.languageenen
dc.publisherTaylor & Francis Australasiaen
dc.relation.ispartofAdvances in Mental Healthen
dc.titleDevelopment of reelin biomarkers to measure psychological resilience and their interaction with 5-HTTLPR in depressionen
dc.typeJournal Articleen
dc.identifier.doi10.1080/18374905.2015.1039188en
dc.subject.keywordsMedical and Health Sciencesen
local.contributor.firstnameSuresh K Aen
local.contributor.firstnameChristopher Fen
local.contributor.firstnameJoelle V Fen
local.contributor.firstnamePierreen
local.contributor.firstnameMurenen
local.contributor.firstnameNeil Aen
local.contributor.firstnameJames Ren
local.subject.for2008119999 Medical and Health Sciences not elsewhere classifieden
local.subject.seo2008920410 Mental Healthen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Rural Medicineen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailsathiap2@une.edu.auen
local.profile.emailcsharpl3@une.edu.auen
local.profile.emailjmoensco@une.edu.auen
local.profile.emailpmoens@une.edu.auen
local.profile.emailmherrid3@une.edu.auen
local.profile.emailnsmart2@une.edu.auen
local.profile.emailjmcfarla@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20150709-121913en
local.publisher.placeAustraliaen
local.format.startpage7en
local.format.endpage17en
local.identifier.scopusid84942250766en
local.peerreviewedYesen
local.identifier.volume13en
local.identifier.issue1en
local.contributor.lastnamePalanisamyen
local.contributor.lastnameSharpleyen
local.contributor.lastnameCoumansen
local.contributor.lastnameMoensen
local.contributor.lastnameHerriden
local.contributor.lastnameSmarten
local.contributor.lastnameMcFarlaneen
dc.identifier.staffune-id:sathiap2en
dc.identifier.staffune-id:csharpl3en
dc.identifier.staffune-id:jmoenscoen
dc.identifier.staffune-id:pmoensen
dc.identifier.staffune-id:mherrid3en
dc.identifier.staffune-id:nsmart2en
dc.identifier.staffune-id:jmcfarlaen
local.profile.orcid0000-0001-7922-4848en
local.profile.orcid0000-0001-6642-5202en
local.profile.orcid0000-0003-3121-5306en
local.profile.orcid0000-0002-8290-6409en
local.profile.orcid0000-0003-4429-5384en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:18725en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleDevelopment of reelin biomarkers to measure psychological resilience and their interaction with 5-HTTLPR in depressionen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorPalanisamy, Suresh K Aen
local.search.authorSharpley, Christopher Fen
local.search.authorCoumans, Joelle V Fen
local.search.authorMoens, Pierreen
local.search.authorHerrid, Murenen
local.search.authorSmart, Neil Aen
local.search.authorMcFarlane, James Ren
local.uneassociationUnknownen
local.year.published2015en
local.subject.for2020320903 Central nervous systemen
local.subject.seo2020200409 Mental healthen
local.codeupdate.date2021-10-24T07:20:06.478en
local.codeupdate.epersoncsharpl3@une.edu.auen
local.codeupdate.finalisedtrueen
local.original.for2020undefineden
local.original.seo2020200409 Mental healthen
Appears in Collections:Journal Article
School of Science and Technology
Files in This Item:
2 files
File Description SizeFormat 
Show simple item record

SCOPUSTM   
Citations

1
checked on Nov 18, 2023

Page view(s)

2,442
checked on Nov 19, 2023

Download(s)

2
checked on Nov 19, 2023
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.