Can the marsh score of coeliac patients be accurately predicted using mathematical modelling of gene expression data from a novel, coeliac-specific PCR-array?

Charlesworth, Richard; Andronicos, Nicholas; Scott, David; Agnew, Linda

doi:10.1111/jgh.13089

Author(s)

Charlesworth, Richard

Andronicos, Nicholas

Scott, David

Agnew, Linda

Publication Date

2015

Abstract

Aims: To date, there is currently no PCR-based array that is specifically focused on the immune pathways and processes of Coeliac Disease (CD). Therefore, the aim of this study was to develop such an array and use mathematical and statistical modelling to generate a set of predictive equations to attempt to diagnose the Marsh score of CD patients using only gene expression data. Methods: This study used bioinformatic analysis to design a CD specific PCR-based array, this array was then used to test cDNA isolated from patients with untreated CD, treated CD and healthy controls. This expression data was then used to design a set of predictive algorithms to attempt to diagnose patient Marsh score on the basis of gene expression data alone.

Citation

Journal of Gastroenterology and Hepatology, 30(Supplement S3), p. 30-31

ISSN

1440-1746

0815-9319

Link

https://hdl.handle.net/1959.11/18462

Language

Publisher

Wiley-Blackwell Publishing Asia

Title

Can the marsh score of coeliac patients be accurately predicted using mathematical modelling of gene expression data from a novel, coeliac-specific PCR-array?

Type of document

Conference Publication

Entity Type

Publication

Author(s)	Charlesworth, Richard Andronicos, Nicholas Scott, David Agnew, Linda
Publication Date	2015
Abstract	Aims: To date, there is currently no PCR-based array that is specifically focused on the immune pathways and processes of Coeliac Disease (CD). Therefore, the aim of this study was to develop such an array and use mathematical and statistical modelling to generate a set of predictive equations to attempt to diagnose the Marsh score of CD patients using only gene expression data. Methods: This study used bioinformatic analysis to design a CD specific PCR-based array, this array was then used to test cDNA isolated from patients with untreated CD, treated CD and healthy controls. This expression data was then used to design a set of predictive algorithms to attempt to diagnose patient Marsh score on the basis of gene expression data alone.
Citation	Journal of Gastroenterology and Hepatology, 30(Supplement S3), p. 30-31
ISSN	1440-1746 0815-9319
Link	https://hdl.handle.net/1959.11/18462
Language	en
Publisher	Wiley-Blackwell Publishing Asia
Title	Can the marsh score of coeliac patients be accurately predicted using mathematical modelling of gene expression data from a novel, coeliac-specific PCR-array?
Type of document	Conference Publication
Entity Type	Publication

Can the marsh score of coeliac patients be accurately predicted using mathematical modelling of gene expression data from a novel, coeliac-specific PCR-array?

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