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Title: Can the marsh score of coeliac patients be accurately predicted using mathematical modelling of gene expression data from a novel, coeliac-specific PCR-array?
Contributor(s): Charlesworth, Richard (author); Andronicos, Nicholas  (author)orcid ; Scott, David (author); Agnew, Linda  (author)orcid 
Publication Date: 2015
DOI: 10.1111/jgh.13089
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Abstract: Aims: To date, there is currently no PCR-based array that is specifically focused on the immune pathways and processes of Coeliac Disease (CD). Therefore, the aim of this study was to develop such an array and use mathematical and statistical modelling to generate a set of predictive equations to attempt to diagnose the Marsh score of CD patients using only gene expression data. Methods: This study used bioinformatic analysis to design a CD specific PCR-based array, this array was then used to test cDNA isolated from patients with untreated CD, treated CD and healthy controls. This expression data was then used to design a set of predictive algorithms to attempt to diagnose patient Marsh score on the basis of gene expression data alone.
Publication Type: Conference Publication
Conference Name: World Congress of Gastroenterology, Brisbane, Australia, 28th September - 2nd October, 2015
Conference Details: World Congress of Gastroenterology, Brisbane, Australia, 28th September - 2nd October, 2015
Source of Publication: Journal of Gastroenterology and Hepatology, 30(Supplement S3), p. 30-31
Publisher: Wiley-Blackwell Publishing Asia
Place of Publication: Australia
ISSN: 0815-9319
Field of Research (FOR): 110307 Gastroenterology and Hepatology
110703 Autoimmunity
Socio-Economic Outcome Codes: 920105 Digestive System Disorders
920108 Immune System and Allergy
HERDC Category Description: E3 Extract of Scholarly Conference Publication
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