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Title: Functional Analysis of Putative Cardio-Protective Agents in Reperfusion of Whole Rat Heart and Isolated Rat Cardiomyocytes
Contributor(s): Almashhadany, Amer Hasan (author); Jones, Graham (supervisor)orcid ; van der Touw, Tom (supervisor)
Conferred Date: 2015
Copyright Date: 2015
Open Access: Yes
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Abstract: The amino acids, glycine and glutamine have been implicated in myocardial protection against damage which occurs when the ischaemic heart is reperfused. A major focus of this thesis was to investigate whether such protection could be enhanced by simultaneously delivering these amino acids as the dipeptide, L-glycyl-L-glutamine (gly-gln). In addition homocysteine has been implicated in augmented oxidative stress, and recognized as a risk factor for developing cardiovascular disease, but is structurally related to the cardioprotective agent cysteine. A second aim, therefore, was to investigate the little known effects of homocysteine on heart cells.
Publication Type: Thesis Masters Research
Field of Research Codes: 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics)
111601 Cell Physiology
110201 Cardiology (incl Cardiovascular Diseases)
Rights Statement: Copyright 2015 - Amer Hasan Almashhadany
HERDC Category Description: T1 Thesis - Masters Degree by Research
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