Clinical application of low-dose phase contrast breast CT: methods for the optimization of the reconstruction workflow

Author(s)
Pacile, S
Brun, F
Accardo, A
Tromba, G
Gureyev, Timur
Dullin, C
Nesterets, Yakov
Dreossi, D
Mohammadi, S
Tonutti, M
Stacul, F
Lockie, D
Zanconati, F
Publication Date
2015
Abstract
Results are presented of a feasibility study of three-dimensional X-ray tomographic mammography utilising in-line phase contrast. Experiments were performed at SYRMEP beamline of Elettra synchrotron. A specially designed plastic phantom and a mastectomy sample containing a malignant lesion were used to study the reconstructed image quality as a function of different image processing operations. Detailed evaluation and optimization of image reconstruction workflows have been carried out using combinations of several advanced computed tomography algorithms with different pre-processing and post-processing steps. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. A number of objective image quality indices have been applied for quantitative evaluation of the results, and these were compared with subjective assessments of the same images by three experienced radiologists and one pathologist. The outcomes of this study provide practical guidelines for the optimization of image processing workflows in synchrotron-based phase-contrast mammo-tomography.
Citation
Biomedical Optics Express, 6(8), p. 3099-3112
ISSN
2156-7085
Link
Publisher
Optical Society of America
Title
Clinical application of low-dose phase contrast breast CT: methods for the optimization of the reconstruction workflow
Type of document
Journal Article
Entity Type
Publication

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