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Title: Clinical application of low-dose phase contrast breast CT: methods for the optimization of the reconstruction workflow
Contributor(s): Pacile, S (author); Brun, F (author); Accardo, A (author); Tromba, G (author); Gureyev, Timur  (author)orcid ; Dullin, C (author); Nesterets, Yakov  (author); Dreossi, D (author); Mohammadi, S (author); Tonutti, M (author); Stacul, F (author); Lockie, D (author); Zanconati, F (author)
Publication Date: 2015
Open Access: Yes
DOI: 10.1364/boe.6.003099Open Access Link
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Abstract: Results are presented of a feasibility study of three-dimensional X-ray tomographic mammography utilising in-line phase contrast. Experiments were performed at SYRMEP beamline of Elettra synchrotron. A specially designed plastic phantom and a mastectomy sample containing a malignant lesion were used to study the reconstructed image quality as a function of different image processing operations. Detailed evaluation and optimization of image reconstruction workflows have been carried out using combinations of several advanced computed tomography algorithms with different pre-processing and post-processing steps. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. A number of objective image quality indices have been applied for quantitative evaluation of the results, and these were compared with subjective assessments of the same images by three experienced radiologists and one pathologist. The outcomes of this study provide practical guidelines for the optimization of image processing workflows in synchrotron-based phase-contrast mammo-tomography.
Publication Type: Journal Article
Source of Publication: Biomedical Optics Express, 6(8), p. 3099-3112
Publisher: Optical Society of America
Place of Publication: Washington DC, United States of America
ISSN: 2156-7085
Field of Research (FOR): 020501 Classical and Physical Optics
029903 Medical Physics
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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