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https://hdl.handle.net/1959.11/18297
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DC Field | Value | Language |
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dc.contributor.author | Almashhadany, Amer | en |
dc.contributor.author | Shackebaei, Dareuosh | en |
dc.contributor.author | van der Touw, Tom | en |
dc.contributor.author | Jones, Graham L | en |
dc.contributor.author | Suleiman, M Saadeh | en |
dc.contributor.author | King, Nicola | en |
dc.date.accessioned | 2015-12-23T11:23:00Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Cellular Physiology and Biochemistry, 37(6), p. 2265-2274 | en |
dc.identifier.issn | 1421-9778 | en |
dc.identifier.issn | 1015-8987 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/18297 | - |
dc.description.abstract | Background/Aims: Hyperhomocysteinaemia is recognised as a strong independent risk factor for developing cardiovascular disease. This study investigated how an acute homocysteine dose affected cardiac performance during ischaemia reperfusion and cardiomyocyte contractility and morphology under normal conditions and during oxidative stress. Methods: Cardiac function was measured in isolated and perfused rat hearts before and after 40 minutes' global normothermic ischaemia. Where used, 0.1 mM L-homocysteine was present prior to, and throughout ischaemia, before wash out after 10 minutes' reperfusion. Calcium transients under normal conditions and changes in contractile synchronicity during oxidative stress (exposure to 0.2 mM H2O2) were measured in freshly isolated rat cardiomyocytes incubated for 60 minutes ± 0.1 mM L-homocysteine. Results: During ischaemia reperfusion 0.1 mM L-homocysteine significantly reduced the rate pressure product during reperfusion (10,038 ± 749 vs. 5955 ± 567 mmHg bpm, p < 0.001), but did not affect time to ischaemic contracture. Incubation of freshly isolated cardiomyocytes with 0.1 mM L-homocysteine significantly decreased the amplitude of the calcium transient and slowed the time to half relaxation. Conclusions: These findings suggest that homocysteine exposure affected myocardial recovery from ischaemia and contractile homeostasis although the exact mechanisms for these changes remain to be determined. | en |
dc.language | en | en |
dc.publisher | S Karger AG | en |
dc.relation.ispartof | Cellular Physiology and Biochemistry | en |
dc.title | Homocysteine Exposure Impairs Myocardial Resistance to Ischaemia Reperfusion and Oxidative Stress | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1159/000438582 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Animal Physiology - Systems | en |
dc.subject.keywords | Medical and Health Sciences | en |
dc.subject.keywords | Biochemistry and Cell Biology | en |
local.contributor.firstname | Amer | en |
local.contributor.firstname | Dareuosh | en |
local.contributor.firstname | Tom | en |
local.contributor.firstname | Graham L | en |
local.contributor.firstname | M Saadeh | en |
local.contributor.firstname | Nicola | en |
local.subject.for2008 | 060199 Biochemistry and Cell Biology not elsewhere classified | en |
local.subject.for2008 | 060603 Animal Physiology - Systems | en |
local.subject.for2008 | 119999 Medical and Health Sciences not elsewhere classified | en |
local.subject.seo2008 | 920103 Cardiovascular System and Diseases | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | tvandert@une.edu.au | en |
local.profile.email | gjones2@une.edu.au | en |
local.profile.email | msuleima@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20151209-175836 | en |
local.publisher.place | Switzerland | en |
local.format.startpage | 2265 | en |
local.format.endpage | 2274 | en |
local.identifier.scopusid | 84949595788 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 37 | en |
local.identifier.issue | 6 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Almashhadany | en |
local.contributor.lastname | Shackebaei | en |
local.contributor.lastname | van der Touw | en |
local.contributor.lastname | Jones | en |
local.contributor.lastname | Suleiman | en |
local.contributor.lastname | King | en |
dc.identifier.staff | une-id:tvandert | en |
dc.identifier.staff | une-id:gjones2 | en |
dc.identifier.staff | une-id:msuleima | en |
local.profile.orcid | 0000-0002-6435-1542 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:18501 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Homocysteine Exposure Impairs Myocardial Resistance to Ischaemia Reperfusion and Oxidative Stress | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Almashhadany, Amer | en |
local.search.author | Shackebaei, Dareuosh | en |
local.search.author | van der Touw, Tom | en |
local.search.author | Jones, Graham L | en |
local.search.author | Suleiman, M Saadeh | en |
local.search.author | King, Nicola | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000368072800017 | en |
local.year.published | 2015 | en |
local.subject.for2020 | 310199 Biochemistry and cell biology not elsewhere classified | en |
local.subject.for2020 | 310910 Animal physiology - systems | en |
local.subject.for2020 | 329999 Other biomedical and clinical sciences not elsewhere classified | en |
local.subject.seo2020 | 200101 Diagnosis of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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