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Title: Effect of ageing and oxidative stress on antioxidant enzyme activity in different regions of the rat kidney
Contributor(s): Thiab, Noor Riyadh (author); King, Nicola (author); Jones, Graham L  (author)orcid 
Publication Date: 2015
DOI: 10.1007/s11010-015-2503-2
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Abstract: Oxidative stress has been implicated in ageing and the pathogenesis of chronic kidney disease. We examined levels of antioxidant enzymes glutathione peroxidase, glutathione reductase, glutathione S-transferase, catalase and superoxide dismutase as modulated by age and oxidative stress in different regions of the kidney. Antioxidant enzymes were examined in different regions of the kidney in male Wistar rats. Kidneys from rats of different ages (5, 12, 36 and 60 weeks) were dissected into cortex, outer medulla and inner medulla. Tissues were incubated for 30 min with or without 0.2 mM H2O2 to induce oxidative stress. Antioxidant enzyme activities progressively decreased with age under both control and stress conditions (P
Publication Type: Journal Article
Source of Publication: Molecular and Cellular Biochemistry, 408(1-2), p. 253-260
Publisher: Springer New York LLC
Place of Publication: New York, United States of America
ISSN: 0300-8177
Field of Research (FOR): 060107 Enzymes
060603 Animal Physiology - Systems
119999 Medical and Health Sciences not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article

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