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Title: A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron
Contributor(s): Nesterets, Yakov  (author); Gureyev, Timur  (author)orcid ; Tromba, Giuliana (author); Mayo, Sheridan C (author); Stevenson, Andrew W (author); Thompson, Darren (author); Brown, Jeremy M C (author); Kitchen, Marcus J (author); Pavlov, Konstantin M  (author)orcid ; Lockie, Darren (author); Brun, Francesco (author)
Publication Date: 2015
DOI: 10.1107/s160057751501766x
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Abstract: Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low-dose high-sensitivity three-dimensional mammographic phase-contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X-ray energy, source size, detector resolution, sample-to-detector distance, scanning and data processing strategies in the case of propagation-based phase-contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast-tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 mm, revealed the presence of propagation-based phase contrast and demonstrated significant improvement of the quality of phase-contrast CT imaging compared with conventional (absorption-based) CT, at medically acceptable radiation doses.
Publication Type: Journal Article
Grant Details: ARC/SR120200004
Source of Publication: Journal of Synchrotron Radiation, 22(6), p. 1509-1523
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: United Kingdom
ISSN: 0909-0495
Field of Research (FOR): 029903 Medical Physics
029904 Synchrotrons; Accelerators; Instruments and Techniques
020599 Optical Physics not elsewhere classified
Socio-Economic Outcome Codes: 861502 Medical Instruments
920102 Cancer and Related Disorders
861503 Scientific Instruments
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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