The sheep genome illuminates biology of the rumen and lipid metabolism

2014

Jiang, Yu

Xie, Min

Stanton, Jo-Ann

Brauning, Rudiger

Barris, Wesley C

Hourlier, Thibaut

Aken, Bronwen L

Searle, Stephen M J

Adelson, David L

Bian, Chao

Cam, Graham R

Chen, Yulin

Chen, Wenbin

Cheng, Shifeng

DeSilva, Udaya

Dixen, Karen

Dong, Yang

Fan, Guangyi

Franklin, Ian R

Fu, Shaoyin

Fuentes-Utrilla, Pablo

Guan, Rui

Highland, Margaret A

Talbot, Richard

Holder, Michael E

Huang, Guodong

Ingham, Aaron B

Jhangiani, Shalini N

Kalra, Divya

Kovar, Christie L

Lee, Sandra

Liu, Weiqing

Liu, Xin

Lu, Changxin

Maddox, Jillian F

Lv, Tian

Mathew, Tittu

McWilliam, Sean

Menzies, Moira

Pan, Shengkai

Robelin, David

Servin, Bertrand

Townley, David

Wang, Wenliang

Wei, Bin

Faraut, Thomas

White, Stephen N

Yang, Xinhua

Ye, Chen

Yue, Yaojing

Zeng, Peng

Zhou, Qing

Hansen, Jacob B

Kristiansen, Karsten

Gibbs, Richard A

Flicek, Paul

Wu, Chunhua

Warkup, Christopher C

Jones, Huw E

Oddy, Hutton

Nicholas, Frank W

McEwan, John C

Kijas, James W

Wang, Jun

Worley, Kim C

Archibald, Alan L

Cockett, Noelle

Muzny, Donna M

Xu, Xun

Wang, Wen

Dalrymple, Brian P

Li, Yuxiang

Zhang, Wenguang

Journal Article

en

Publication

American Association for the Advancement of Science (AAAS)

United States of America

10.1126/science.1252806

une:18024

Sheep ('Ovis aries') are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

link

Science, 344(6188), p. 1168-1173

1095-9203

0036-8075

1168

1173