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Title: The sheep genome illuminates biology of the rumen and lipid metabolism
Contributor(s): Jiang, Yu (author); Xie, Min (author); Stanton, Jo-Ann (author); Brauning, Rudiger (author); Barris, Wesley C (author); Hourlier, Thibaut (author); Aken, Bronwen L (author); Searle, Stephen M J (author); Adelson, David L (author); Bian, Chao (author); Cam, Graham R (author); Chen, Yulin (author); Chen, Wenbin (author); Cheng, Shifeng (author); DeSilva, Udaya (author); Dixen, Karen (author); Dong, Yang (author); Fan, Guangyi (author); Franklin, Ian R (author); Fu, Shaoyin (author); Fuentes-Utrilla, Pablo (author); Guan, Rui (author); Highland, Margaret A (author); Talbot, Richard (author); Holder, Michael E (author); Huang, Guodong (author); Ingham, Aaron B (author); Jhangiani, Shalini N (author); Kalra, Divya (author); Kovar, Christie L (author); Lee, Sandra (author); Liu, Weiqing (author); Liu, Xin (author); Lu, Changxin (author); Maddox, Jillian F (author); Lv, Tian (author); Mathew, Tittu (author); McWilliam, Sean (author); Menzies, Moira (author); Pan, Shengkai (author); Robelin, David (author); Servin, Bertrand (author); Townley, David (author); Wang, Wenliang (author); Wei, Bin (author); Faraut, Thomas (author); White, Stephen N (author); Yang, Xinhua (author); Ye, Chen (author); Yue, Yaojing (author); Zeng, Peng (author); Zhou, Qing (author); Hansen, Jacob B (author); Kristiansen, Karsten (author); Gibbs, Richard A (author); Flicek, Paul (author); Wu, Chunhua (author); Warkup, Christopher C (author); Jones, Huw E (author); Oddy, Hutton  (author)orcid ; Nicholas, Frank W (author); McEwan, John C (author); Kijas, James W (author); Wang, Jun (author); Worley, Kim C (author); Archibald, Alan L (author); Cockett, Noelle (author); Muzny, Donna M (author); Xu, Xun (author); Wang, Wen (author); Dalrymple, Brian P (author); Li, Yuxiang (author); Zhang, Wenguang (author)
Publication Date: 2014
Open Access: Yes
DOI: 10.1126/science.1252806Open Access Link
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Open Access Link: Access Link
Abstract: Sheep ('Ovis aries') are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
Publication Type: Journal Article
Source of Publication: Science, 344(6188), p. 1168-1173
Publisher: American Association for the Advancement of Science
Place of Publication: United States of America
ISSN: 0036-8075
Field of Research (FOR): 070201 Animal Breeding
070202 Animal Growth and Development
070204 Animal Nutrition
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
830311 Sheep - Wool
830310 Sheep - Meat
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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