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|Title:||A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape||Contributor(s):||Leamy, L J (author); Klingenberg, C P (author); Sherratt, Emma (author); Wolf, Jason B (author); Cheverud, James M (author)||Publication Date:||2008||DOI:||10.1038/hdy.2008.79||Handle Link:||https://hdl.handle.net/1959.11/17759||Abstract:||Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F3 population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting.||Publication Type:||Journal Article||Source of Publication:||Heredity, 101(6), p. 518-526||Publisher:||Nature Publishing Group||Place of Publication:||United Kingdom||ISSN:||1365-2540
|Field of Research (FOR):||060411 Population, Ecological and Evolutionary Genetics||Socio-Economic Outcome Codes:||970106 Expanding Knowledge in the Biological Sciences||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 213
|Appears in Collections:||Journal Article|
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