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https://hdl.handle.net/1959.11/17759
Title: | A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape | Contributor(s): | Leamy, L J (author); Klingenberg, C P (author); Sherratt, Emma (author); Wolf, Jason B (author); Cheverud, James M (author) | Publication Date: | 2008 | DOI: | 10.1038/hdy.2008.79 | Handle Link: | https://hdl.handle.net/1959.11/17759 | Abstract: | Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F3 population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting. | Publication Type: | Journal Article | Source of Publication: | Heredity, 101(6), p. 518-526 | Publisher: | Nature Publishing Group | Place of Publication: | United Kingdom | ISSN: | 1365-2540 0018-067X |
Fields of Research (FoR) 2008: | 060411 Population, Ecological and Evolutionary Genetics | Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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