Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/17726
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dc.contributor.authorEbejer, Janeen
dc.contributor.authorMedland, Sarahen
dc.contributor.authorVan Der Werf, Julius Hen
dc.contributor.authorWright, M Jen
dc.contributor.authorHenders, A Ken
dc.contributor.authorGillespie, N Aen
dc.contributor.authorHickie, I Ben
dc.contributor.authorMartin, Nicholasen
dc.contributor.authorDuffy, D Len
dc.date.accessioned2015-07-28T16:56:00Z-
dc.date.issued2015-
dc.identifier.citationBehavior Genetics, 45(1), p. 35-50en
dc.identifier.issn1573-3297en
dc.identifier.issn0001-8244en
dc.identifier.urihttps://hdl.handle.net/1959.11/17726-
dc.description.abstractThe heritability of attention-deficit/hyperactivity disorder (ADHD) is higher for children than adults. This may be due to increasing importance of environment in symptom variation, measurement inaccuracy when two raters report behavior of a twin-pair, a contrast effect resulting from parental comparison of siblings and/or dimensionality of measures. We examine rater contrast and sex effects in ADHD subtypes using a dimensional scale and compare the aetiology of self, versus maternal-report. Data were collected using the Strengths and Weaknesses of ADHD and Normal Behaviour Scale (SWAN): maternal-report for 3,223 twins and siblings (mean age 21.2, SD = 6.3) and self-report for 1,617 twins and siblings (mean age 25.5, SD = 3.2). Contrast effects and magnitude of genetic and environmental contributions to variance of ADHD phenotypes (inattention, hyperactivity-impulsivity, combined behaviours) were examined using structural equation modeling. Contrast effects were evident for maternal-report hyperactivity-impulsivity (b = −0.04) and self-report inattention (−0.09) and combined ADHD (−0.08). Dominant genetic effects were shared by raters for inattention, hyperactivity-impulsivity and combined ADHD. Broad-sense heritability was equal across sex for maternal-report inattention, hyperactivity-impulsivity and combined ADHD (0.72, 0.83, 0.80). Heritability for corresponding subtypes in self-reported data were best represented by sex (0.46, 0.30, 0.39 for males; 0.69, 0.41, 0.65 for females). Heritability difference between maternal and self-report ADHD was due to greater variance of male specific environment in self-report data. Self-reported ADHD differed across sex by magnitude of specific environment and genetic effects.en
dc.languageenen
dc.publisherSpringer New York LLCen
dc.relation.ispartofBehavior Geneticsen
dc.titleContrast Effects and Sex Influence Maternal and Self-Report Dimensional Measures of Attention-Deficit Hyperactivity Disorderen
dc.typeJournal Articleen
dc.identifier.doi10.1007/s10519-014-9670-xen
dc.subject.keywordsPublic Health and Health Servicesen
local.contributor.firstnameJaneen
local.contributor.firstnameSarahen
local.contributor.firstnameJulius Hen
local.contributor.firstnameM Jen
local.contributor.firstnameA Ken
local.contributor.firstnameN Aen
local.contributor.firstnameI Ben
local.contributor.firstnameNicholasen
local.contributor.firstnameD Len
local.subject.for2008111799 Public Health and Health Services not elsewhere classifieden
local.subject.seo2008920410 Mental Healthen
local.profile.schoolSchool of Humanities, Arts and Social Sciencesen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolNeuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United Statesen
local.profile.schoolGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australiaen
local.profile.schoolGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia, Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United Statesen
local.profile.schoolBrain and Mind Research Institute, University of Sydney, Sydney, NSW, Australiaen
local.profile.schoolRural Medical Schoolen
local.profile.schoolGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australiaen
local.profile.emailjebejer2@une.edu.auen
local.profile.emailsmedland@une.edu.auen
local.profile.emailjvanderw@une.edu.auen
local.profile.emailnmarti24@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20150708-114932en
local.publisher.placeUnited States of Americaen
local.format.startpage35en
local.format.endpage50en
local.identifier.scopusid84920757448en
local.peerreviewedYesen
local.identifier.volume45en
local.identifier.issue1en
local.contributor.lastnameEbejeren
local.contributor.lastnameMedlanden
local.contributor.lastnameVan Der Werfen
local.contributor.lastnameWrighten
local.contributor.lastnameHendersen
local.contributor.lastnameGillespieen
local.contributor.lastnameHickieen
local.contributor.lastnameMartinen
local.contributor.lastnameDuffyen
dc.identifier.staffune-id:jebejer2en
dc.identifier.staffune-id:smedlanden
dc.identifier.staffune-id:jvanderwen
dc.identifier.staffune-id:nmarti24en
local.profile.orcid0000-0003-2512-1696en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:17938en
local.identifier.handlehttps://hdl.handle.net/1959.11/17726en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleContrast Effects and Sex Influence Maternal and Self-Report Dimensional Measures of Attention-Deficit Hyperactivity Disorderen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorEbejer, Janeen
local.search.authorMedland, Sarahen
local.search.authorVan Der Werf, Julius Hen
local.search.authorWright, M Jen
local.search.authorHenders, A Ken
local.search.authorGillespie, N Aen
local.search.authorHickie, I Ben
local.search.authorMartin, Nicholasen
local.search.authorDuffy, D Len
local.uneassociationUnknownen
local.identifier.wosid000348279200004en
local.year.published2015en
local.subject.for2020420399 Health services and systems not elsewhere classifieden
local.subject.seo2020200409 Mental healthen
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