Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/17672
Title: Skin transcriptome profiles associated with coat color in sheep
Contributor(s): Fan, Ruiwen (author); Xie, Jianshan (author); Gao, Wenjun (author); He, Xiaoyan (author); Yao, Jianbo (author); Smith, George W (author); Dong, Changsheng (author); Bai, Junming (author); Wang, Haidong (author); Tian, Xue (author); Bai, Rui (author); Jia, Xiaoyun (author); Yang, Lei (author); Song, Yunfei (author); Herrid, Muren  (author)
Publication Date: 2013
Open Access: Yes
DOI: 10.1186/1471-2164-14-389Open Access Link
Handle Link: https://hdl.handle.net/1959.11/17672
Abstract: Background: Previous molecular genetic studies of physiology and pigmentation of sheep skin have focused primarily on a limited number of genes and proteins. To identify additional genes that may play important roles in coat color regulation, Illumina sequencing technology was used to catalog global gene expression profiles in skin of sheep with white versus black coat color. Results: There were 90,006 and 74,533 unigenes assembled from the reads obtained from white and black sheep skin, respectively. Genes encoding for the ribosomal proteins and keratin associated proteins were most highly expressed. A total of 2,235 known genes were differentially expressed in black versus white sheep skin, with 479 genes up-regulated and 1,756 genes down-regulated. A total of 845 novel genes were differentially expressed in black versus white sheep skin, consisting of 107 genes which were up-regulated (including 2 highly expressed genes exclusively expressed in black sheep skin) and 738 genes that were down-regulated. There was also a total of 49 known coat color genes expressed in sheep skin, from which 13 genes showed higher expression in black sheep skin. Many of these up-regulated genes, such as DCT, MATP, TYR and TYRP1, are members of the components of melanosomes and their precursor ontology category. Conclusion: The white and black sheep skin transcriptome profiles obtained provide a valuable resource for future research to understand the network of gene expression controlling skin physiology and melanogenesis in sheep.
Publication Type: Journal Article
Source of Publication: BMC Genomics, v.14, p. 1-12
Publisher: BioMed Central Ltd
Place of Publication: United Kingdom
ISSN: 1471-2164
Field of Research (FOR): 060408 Genomics
060109 Proteomics and Intermolecular Interactions (excl Medical Proteomics)
070201 Animal Breeding
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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