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Title: Towards the control of necrotic enteritis in poultry with in-feed antibiotics phasing-out worldwide
Contributor(s): Mohamed Sadeq, Shawkat (author); Wu, Shubiao  (author)orcid ; Swick, Robert A  (author)orcid ; Choct, Mingan  (author)orcid 
Publication Date: 2015
Open Access: Yes
DOI: 10.1016/j.aninu.2015.02.004Open Access Link
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Abstract: Poultry production has undergone a substantial increase compared to the livestock industries since 1970. However, the industry worldwide is now facing challenges with the removal of in-feed antibiotics completely or gradually, as the once well-controlled poultry diseases have re-emerged to cause tremendous loss of production. Necrotic enteritis (NE) is one of the most important diseases which costs the industry over two billion dollars annually. In this paper, we review the progress on the etiology of NE and its control through dietary modifications, pre- and probiotics, short chain fatty acids, and vaccination. The other likely measures resulted in the most advances in the toxin characterization are also discussed. Vaccine strategies may have greater potential for the control of NE mainly due to clearer etiology of NE having been elucidated in recent years with the identification of necrotic enteritis toxin B-like (NetB) toxin. Therefore, the use of alternatives to in-feed antibiotics with a better understanding of the relationship between nutrition and NE, and limiting exposure to infectious agents through biosecurity and vaccination, might be a tool to reduce the incidence of NE and to improve gut health in the absence of in-feed antibiotics. More importantly, the combinations of different measures may achieve greater protection of birds against the disease. Among all the alternatives investigated, prebiotics, organic acids and vaccination have shown improved gastrointestinal health and thus, have potential for the control of NE.
Publication Type: Journal Article
Source of Publication: Animal Nutrition, 1(1), p. 1-11
Publisher: Elsevier BV
Place of Publication: China
ISSN: 2405-6545
Field of Research (FOR): 070204 Animal Nutrition
070205 Animal Protection (Pests and Pathogens)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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