Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/17190
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dc.contributor.authorTschopp, Patricken
dc.contributor.authorSherratt, Emmaen
dc.contributor.authorSanger, Thomas Jen
dc.contributor.authorGroner, Anna Cen
dc.contributor.authorAspiras, Ariel Cen
dc.contributor.authorHu, Jimmy Ken
dc.contributor.authorPourquie, Olivieren
dc.contributor.authorGros, Jeromeen
dc.contributor.authorTabin, Clifford Jen
dc.date.accessioned2015-05-06T17:12:00Z
dc.date.issued2014en
dc.identifier.citationNature, 516(7531), p. 391-394en
dc.identifier.issn0028-0836en
dc.identifier.issn1476-4687en
dc.identifier.urihttps://hdl.handle.net/1959.11/17190en
dc.description.abstractThe move of vertebrates to a terrestrial lifestyle required major adaptations in their locomotory apparatus and reproductive organs. While the fin-to-limb transition has received considerable attention, little is known about the developmental and evolutionary origins of external genitalia. Similarities in gene expression have been interpreted as a potential evolutionary link between the limb and genitals; however,no underlying developmental mechanism has been identified. We re-examined this question using micro-computed tomography, lineage tracing in three amniote clades, and RNA-sequencing-based transcriptional profiling. Here we show that the developmental origin of external genitalia has shifted through evolution, and in some taxa limbs and genitals share a common primordium. In squamates, the genitalia develop directly from the budding hind limbs, or the remnants thereof, whereas in mice the genital tubercle originates from the ventral and tail bud mesenchyme. The recruitment of different cell populations for genital outgrowth follows a change in the relative position of the cloaca, the genitalia organizing centre. Ectopic grafting of the cloaca demonstrates the conserved ability of different mesenchymal cells to respond to these genitalia-inducing signals.Our results support a limb-like developmental origin of external genitalia as the ancestral condition. Moreover, they suggest that a change in the relative position of the cloacal signalling centre during evolution has led to an altered developmental route for external genitalia in mammals, while preserving parts of the ancestral limb molecular circuitry owing to a common evolutionary origin.en
dc.languageenen
dc.publisherNature Publishing Groupen
dc.relation.ispartofNatureen
dc.titleA relative shift in cloacal location repositions external genitalia in amniote evolutionen
dc.typeJournal Articleen
dc.identifier.doi10.1038/nature13819en
dcterms.accessRightsGreenen
dc.subject.keywordsEvolution of Developmental Systemsen
local.contributor.firstnamePatricken
local.contributor.firstnameEmmaen
local.contributor.firstnameThomas Jen
local.contributor.firstnameAnna Cen
local.contributor.firstnameAriel Cen
local.contributor.firstnameJimmy Ken
local.contributor.firstnameOlivieren
local.contributor.firstnameJeromeen
local.contributor.firstnameClifford Jen
local.subject.for2008060305 Evolution of Developmental Systemsen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolZoologyen
local.profile.emailesherrat@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20150302-141437en
local.publisher.placeUnited Kingdomen
local.format.startpage391en
local.format.endpage394en
local.url.openhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294627en
local.peerreviewedYesen
local.identifier.volume516en
local.identifier.issue7531en
local.access.fulltextYesen
local.contributor.lastnameTschoppen
local.contributor.lastnameSherratten
local.contributor.lastnameSangeren
local.contributor.lastnameGroneren
local.contributor.lastnameAspirasen
local.contributor.lastnameHuen
local.contributor.lastnamePourquieen
local.contributor.lastnameGrosen
local.contributor.lastnameTabinen
dc.identifier.staffune-id:esherraten
local.profile.roleauthoren
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local.profile.roleauthoren
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local.profile.roleauthoren
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local.identifier.unepublicationidune:17403en
local.identifier.handlehttps://hdl.handle.net/1959.11/17190en
dc.identifier.academiclevelAcademicen
local.title.maintitleA relative shift in cloacal location repositions external genitalia in amniote evolutionen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 369<br />Views: 380<br />Downloads: 2en
local.search.authorTschopp, Patricken
local.search.authorSherratt, Emmaen
local.search.authorSanger, Thomas Jen
local.search.authorGroner, Anna Cen
local.search.authorAspiras, Ariel Cen
local.search.authorHu, Jimmy Ken
local.search.authorPourquie, Olivieren
local.search.authorGros, Jeromeen
local.search.authorTabin, Clifford Jen
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