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Title: Genome-Wide Association Study on Body Weight Reveals Major Loci on OAR6 in Australian Merino Sheep
Contributor(s): Al-Mamun, Hawlader A (author); Clark, Sam A  (author)orcid ; Kwan, Paul H  (author); Gondro, Cedric  (author)orcid 
Publication Date: 2014
Open Access: Yes
DOI: 10.1186/s12711-015-0142-4Open Access Link
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Abstract: Body weight (BW) is an important trait for meat production in sheep. In order to clarify genes and chromosomal regions that might be associated with body weight in sheep, a genome-wide association study using Illumina 50K Ovine SNP chip on a population of 1,743 Australian Merino sheep was carried out. A total of 39 SNPs were found to be associated with BW at Bonferroni-corrected genome-wide significance of 1%. One region on OAR6, between 40.3 Mb and 42.9 Mb, included 13 significant SNPs that were identified as being associated with the trait. The most significant SNP (OAR6_41936490.1) has 2.11 kg of allele substitution effect, while the second most significant SNP (s17946.1) has 2.13 kg of effect on body weight. These correspond to 24.33% and 24.57%, respectively, of the phenotypic standard deviations for BW in Australian Merino sheep.
Publication Type: Conference Publication
Conference Name: WCGALP 2014: 10th World Congress on Genetics Applied to Livestock Production, Vancouver, Canada, 17th - 22nd August, 2014
Conference Details: WCGALP 2014: 10th World Congress on Genetics Applied to Livestock Production, Vancouver, Canada, 17th - 22nd August, 2014
Grant Details: ARC/DP130100542
Source of Publication: Proceedings of the 10th World Congress on Genetics Applied to Livestock Production (WCGALP) (Genetics of Trait Complexes: Growth and development (Posters)), p. 1-3
Publisher: American Society of Animal Science
Place of Publication: Champaign, United States of America
Field of Research (FOR): 080301 Bioinformatics Software
080109 Pattern Recognition and Data Mining
070201 Animal Breeding
Socio-Economic Outcome Codes: 830311 Sheep - Wool
890201 Application Software Packages (excl. Computer Games)
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
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