Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/16992
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dc.contributor.authorIslam, Tanzilaen
dc.contributor.authorWalkden-Brown, Steveen
dc.contributor.authorRenz, Katrinen
dc.contributor.authorIslam, A Fakhrulen
dc.date.accessioned2015-04-22T16:11:00Z
dc.date.created2013en
dc.date.issued2014en
dc.identifier.urihttps://hdl.handle.net/1959.11/16992en
dc.description.abstractThe attenuated MDV-1 Rispens/CVI988 vaccine is widely used to vaccinate chickens worldwide and is the most effective current vaccine against MD. Two experiments were designed to investigate transmission of the Rispens/CVI988 vaccine virus (Rispens/CVI988) between chickens, the viral kinetics and shedding profile of Rispens/CVI988 and very virulent MDV (vvMDV, isolate 02LAR) in single and mixed infections and the effect of vaccination to challenge interval on the protection provided by Rispens/CVI988 against vvMDV challenge. Experiment 1 used 70 specific pathogen free (SPF) chickens in four climate controlled rooms. In three rooms, 10 chickens were vaccinated with one of the three commercial Rispens/CVI988 vaccines at day old and left in contact with 10 unvaccinated chickens. The fourth room held 10 unvaccinated control birds. As determined by MDV-specific qPCR of weekly room dust, PBL and feather samples the commercially available Rispens/CVI988 vaccine virus strains are shed in significant quantities and transmit effectively to in-contact chickens. Experiment 2 used 600 commercial ISA Brown layers of the same age (day old) in 24 isolators. Chickens were vaccinated with Rispens/CVI988 (3200 pfu) and/or challenged with the 02LAR (400 pfu) on days 0, 5, 10 post hatching providing vaccination to challenge intervals (VCI) of -10, -5, 0, 5, 10 days with the negative values indicating challenge prior to vaccination. As determined by MDV-specific qPCR able to differentiate between the viruses, vaccination with Rispens/CVI988 greatly reduced the viral load of vvMDV in PBL and feather cells but only if birds were vaccinated prior challenge.en
dc.languageenen
dc.titleReplication kinetics, shedding, transmission and protective efficacy of Rispens/CVI988 vaccine virus in single and combined infections with very virulent Marek's disease virusen
dc.typeThesis Doctoralen
dcterms.accessRightsUNE Greenen
dc.subject.keywordsVeterinary Pharmacologyen
dc.subject.keywordsAnimal Protection (Pests and Pathogens)en
local.contributor.firstnameTanzilaen
local.contributor.firstnameSteveen
local.contributor.firstnameKatrinen
local.contributor.firstnameA Fakhrulen
local.subject.for2008070710 Veterinary Pharmacologyen
local.subject.for2008070205 Animal Protection (Pests and Pathogens)en
local.subject.seo2008830309 Poultryen
dcterms.RightsStatementCopyright 2013 - Tanzila Islamen
dc.date.conferred2014en
local.thesis.degreelevelDoctoralen
local.thesis.degreenameDoctor of Philosophyen
local.contributor.grantorUniversity of New Englanden
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailtislam3@une.edu.auen
local.profile.emailswalkden@une.edu.auen
local.profile.emailkrenz@une.edu.auen
local.profile.emailfislam2@une.edu.auen
local.output.categoryT2en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune_thesis-20130726-16305en
local.access.fulltextYesen
local.contributor.lastnameIslamen
local.contributor.lastnameWalkden-Brownen
local.contributor.lastnameRenzen
local.contributor.lastnameIslamen
dc.identifier.staffune-id:tislam4en
dc.identifier.staffune-id:swalkdenen
dc.identifier.staffune-id:krenzen
dc.identifier.staffune-id:fislam2en
local.profile.orcid0000-0002-0638-5533en
local.profile.roleauthoren
local.profile.rolesupervisoren
local.profile.rolesupervisoren
local.profile.rolesupervisoren
local.identifier.unepublicationidune:17206en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleReplication kinetics, shedding, transmission and protective efficacy of Rispens/CVI988 vaccine virus in single and combined infections with very virulent Marek's disease virusen
local.output.categorydescriptionT2 Thesis - Doctorate by Researchen
local.description.statisticsepubsVisitors: 340<br />Views: 432<br />Downloads: 52en
local.thesis.borndigitalyesen
local.search.authorIslam, Tanzilaen
local.search.supervisorWalkden-Brown, Steveen
local.search.supervisorRenz, Katrinen
local.search.supervisorIslam, A Fakhrulen
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/ed03312f-3ab8-42ee-80d1-be48976d65a1en
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/4a79225e-fa1f-451f-a54c-e2305d959fc7en
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/24d1a6d2-eef1-42d5-bd33-53ef837edd28en
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/4a6e9d86-9405-42ff-97b7-ba6526faad93en
local.open.fileurlhttps://rune.une.edu.au/web/retrieve/7f1b0c40-1189-490c-a370-93a0e859ec64en
Appears in Collections:School of Environmental and Rural Science
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