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https://hdl.handle.net/1959.11/16952
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DC Field | Value | Language |
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dc.contributor.author | Leamy, Larry J | en |
dc.contributor.author | Klingenberg, Christian Peter | en |
dc.contributor.author | Sherratt, Emma | en |
dc.contributor.author | Wolf, Jason B | en |
dc.contributor.author | Cheverud, James M | en |
dc.date.accessioned | 2015-04-17T12:58:00Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Symmetry, 7(1), p. 146-163 | en |
dc.identifier.issn | 2073-8994 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/16952 | - |
dc.description.abstract | Fluctuating asymmetry (FA), typically measured by variation in the differences between right and left sides of bilateral traits, is commonly used to assess developmental instability (DI) in populations. A previous quantitative trait locus (QTL) investigation using an F₂ intercross mouse population found little evidence of individual loci affecting FA in mandible size, but an abundance of epistatic interactions between loci. Here we extend this work by testing whether these patterns replicate in an F₃ population derived from the same intercross. Using a large number of molecular markers genotyped in over 1200 mice, we uncovered significant interactions between loci (QTLs) affecting FA in mandible size (and shape). Epistasis contributed roughly 20% of the variation in FASIZE and 19% of the variation in FASHAPE at the 0.0001 probability level alone, and was comparable to that previously estimated for the F₂ mice, and much greater than that generated from the few single-locus QTLs affecting the mandible FA traits. The positions of the single-locus and epistatic QTLs for FA that we discovered suggested that logical candidate genes for DI are those controlling size or shape in the traits themselves, and that they may be interacting with genes for heat shock proteins. | en |
dc.language | en | en |
dc.publisher | MDPI AG | en |
dc.relation.ispartof | Symmetry | en |
dc.title | The Genetic Architecture of Fluctuating Asymmetry of Mandible Size and Shape in a Population of Mice: Another Look | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.3390/sym7010146 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Evolutionary Biology | en |
dc.subject.keywords | Quantitative Genetics (incl Disease and Trait Mapping Genetics) | en |
local.contributor.firstname | Larry J | en |
local.contributor.firstname | Christian Peter | en |
local.contributor.firstname | Emma | en |
local.contributor.firstname | Jason B | en |
local.contributor.firstname | James M | en |
local.subject.for2008 | 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) | en |
local.subject.for2008 | 060399 Evolutionary Biology not elsewhere classified | en |
local.subject.seo2008 | 970106 Expanding Knowledge in the Biological Sciences | en |
local.profile.school | Zoology | en |
local.profile.school | Zoology | en |
local.profile.school | Zoology | en |
local.profile.school | Zoology | en |
local.profile.school | Zoology | en |
local.profile.email | esherrat@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20150302-140620 | en |
local.publisher.place | Switzerland | en |
local.format.startpage | 146 | en |
local.format.endpage | 163 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 7 | en |
local.identifier.issue | 1 | en |
local.title.subtitle | Another Look | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Leamy | en |
local.contributor.lastname | Klingenberg | en |
local.contributor.lastname | Sherratt | en |
local.contributor.lastname | Wolf | en |
local.contributor.lastname | Cheverud | en |
dc.identifier.staff | une-id:esherrat | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:17166 | en |
local.identifier.handle | https://hdl.handle.net/1959.11/16952 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | The Genetic Architecture of Fluctuating Asymmetry of Mandible Size and Shape in a Population of Mice | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Leamy, Larry J | en |
local.search.author | Klingenberg, Christian Peter | en |
local.search.author | Sherratt, Emma | en |
local.search.author | Wolf, Jason B | en |
local.search.author | Cheverud, James M | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000352354700007 | en |
local.year.published | 2015 | en |
local.subject.for2020 | 310506 Gene mapping | en |
local.subject.for2020 | 310499 Evolutionary biology not elsewhere classified | en |
local.subject.seo2020 | 280102 Expanding knowledge in the biological sciences | en |
Appears in Collections: | Journal Article |
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