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https://hdl.handle.net/1959.11/16952
Title: | The Genetic Architecture of Fluctuating Asymmetry of Mandible Size and Shape in a Population of Mice: Another Look | Contributor(s): | Leamy, Larry J (author); Klingenberg, Christian Peter (author); Sherratt, Emma (author); Wolf, Jason B (author); Cheverud, James M (author) | Publication Date: | 2015 | Open Access: | Yes | DOI: | 10.3390/sym7010146 | Handle Link: | https://hdl.handle.net/1959.11/16952 | Abstract: | Fluctuating asymmetry (FA), typically measured by variation in the differences between right and left sides of bilateral traits, is commonly used to assess developmental instability (DI) in populations. A previous quantitative trait locus (QTL) investigation using an F₂ intercross mouse population found little evidence of individual loci affecting FA in mandible size, but an abundance of epistatic interactions between loci. Here we extend this work by testing whether these patterns replicate in an F₃ population derived from the same intercross. Using a large number of molecular markers genotyped in over 1200 mice, we uncovered significant interactions between loci (QTLs) affecting FA in mandible size (and shape). Epistasis contributed roughly 20% of the variation in FASIZE and 19% of the variation in FASHAPE at the 0.0001 probability level alone, and was comparable to that previously estimated for the F₂ mice, and much greater than that generated from the few single-locus QTLs affecting the mandible FA traits. The positions of the single-locus and epistatic QTLs for FA that we discovered suggested that logical candidate genes for DI are those controlling size or shape in the traits themselves, and that they may be interacting with genes for heat shock proteins. | Publication Type: | Journal Article | Source of Publication: | Symmetry, 7(1), p. 146-163 | Publisher: | MDPI AG | Place of Publication: | Switzerland | ISSN: | 2073-8994 | Fields of Research (FoR) 2008: | 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) 060399 Evolutionary Biology not elsewhere classified |
Fields of Research (FoR) 2020: | 310506 Gene mapping 310499 Evolutionary biology not elsewhere classified |
Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences | Socio-Economic Objective (SEO) 2020: | 280102 Expanding knowledge in the biological sciences | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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