Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/16952
Title: The Genetic Architecture of Fluctuating Asymmetry of Mandible Size and Shape in a Population of Mice: Another Look
Contributor(s): Leamy, Larry J (author); Klingenberg, Christian Peter (author); Sherratt, Emma (author); Wolf, Jason B (author); Cheverud, James M (author)
Publication Date: 2015
Open Access: Yes
DOI: 10.3390/sym7010146Open Access Link
Handle Link: https://hdl.handle.net/1959.11/16952
Abstract: Fluctuating asymmetry (FA), typically measured by variation in the differences between right and left sides of bilateral traits, is commonly used to assess developmental instability (DI) in populations. A previous quantitative trait locus (QTL) investigation using an F₂ intercross mouse population found little evidence of individual loci affecting FA in mandible size, but an abundance of epistatic interactions between loci. Here we extend this work by testing whether these patterns replicate in an F₃ population derived from the same intercross. Using a large number of molecular markers genotyped in over 1200 mice, we uncovered significant interactions between loci (QTLs) affecting FA in mandible size (and shape). Epistasis contributed roughly 20% of the variation in FASIZE and 19% of the variation in FASHAPE at the 0.0001 probability level alone, and was comparable to that previously estimated for the F₂ mice, and much greater than that generated from the few single-locus QTLs affecting the mandible FA traits. The positions of the single-locus and epistatic QTLs for FA that we discovered suggested that logical candidate genes for DI are those controlling size or shape in the traits themselves, and that they may be interacting with genes for heat shock proteins.
Publication Type: Journal Article
Source of Publication: Symmetry, 7(1), p. 146-163
Publisher: MDPIAG
Place of Publication: Switzerland
ISSN: 2073-8994
Field of Research (FOR): 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
060399 Evolutionary Biology not elsewhere classified
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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