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Title: Exercise Training for Management of Peripheral Arterial Disease: A Systematic Review and Meta-Analysis
Contributor(s): Parmenter, Belinda (author); Dieberg, Gudrun  (author)orcid ; Smart, Neil  (author)orcid 
Publication Date: 2015
DOI: 10.1007/s40279-014-0261-z
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Abstract: Background: Peripheral arterial disease (PAD), a chronic condition with debilitating clinical sequelae, leads to reduced walking activity and increased mortality risk. Objective: We sought to quantify expected benefits elicited via exercise training in people with PAD and aimed to clarify which prescriptions were optimal. Data sources: We conducted a systematic search (Pub- Med, CINAHL, Cochrane controlled trials registry; 1966-31 July 2013). Study selection: We included randomized controlled trials (RCTs) of exercise training versus usual medical care in persons with PAD. Studies were assessed by two reviewers, 41 of 57 (72 %) of RCTs met selection criteria. Data extraction and synthesis: Data extraction sheets were used to record data and two reviewers cross-checked data. Included study authors were asked for missing data. Main outcomes and measures: Primary outcome: change in aerobic capacity (peak VO₂). Secondary outcomes: anklebrachial index (ABI), flow-mediated dilatation, 6-minute walk claudication distances (initial and absolute) and graded treadmill (initial and absolute) distances. The primary hypothesis was that peak VO₂ would increase with exercise training. Using sub-analyses, we also aimed to clarify what types of exercise prescription would provide patients with most benefit; hypotheses were developed a priori.
Publication Type: Journal Article
Source of Publication: Sports Medicine, 45(2), p. 231-244
Publisher: Adis International Ltd
Place of Publication: New Zealand
ISSN: 0112-1642
Field of Research (FOR): 110201 Cardiology (incl Cardiovascular Diseases)
110604 Sports Medicine
110602 Exercise Physiology
Socio-Economic Outcome Codes: 920103 Cardiovascular System and Diseases
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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