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|Title:||Leptin is critical for successful implantation in mice||Contributor(s):||Panwar, Shalini (author); McFarlane, James R (author)||Publication Date:||2006||Handle Link:||https://hdl.handle.net/1959.11/16459||Abstract:||Leptin, a 16kDa polypeptide, has long been known to have a role in reproduction as exogenous leptin administration can reverse the sterility of ob/ob mice which lack functional leptin. Leptin binds to cell surface receptors (Ob-R) and signals via STAT/JAK signal transduction pathway. This ligand receptor system is mandatory for embryonic implantation in rodents as withdrawl of leptin infusion in ob/ob females shortly after fertilization impairs implantation. Leptin and its receptors are expressed in human and mouse endometrium. Leptin has been immunolocalized in human and mouse preimplantation embryos and promotes mouse preimplantation embryo development through Ob-R signaling. The aim of our experiment was to study the impact of blocking leptin signaling in the mouse endometrium by giving intrauterine injections of leptin antiserum on day 1 and day 3 of pregnancy.||Publication Type:||Conference Publication||Conference Name:||37th Annual Scientific Meeting of the Society for Reproductive Biology, Gold Coast, Australia, 20th - 23rd August, 2006||Conference Details:||37th Annual Scientific Meeting of the Society for Reproductive Biology, Gold Coast, Australia, 20th - 23rd August, 2006||Source of Publication:||Society for Reproductive Biology Thirty-Seventh Annual Scientific Meeting Program and Abstracts, p. 81-81||Publisher:||Society for Reproductive Biology||Place of Publication:||online||Field of Research (FOR):||060603 Animal Physiology - Systems||Socio-Economic Outcome Codes:||970111 Expanding Knowledge in the Medical and Health Sciences||HERDC Category Description:||E3 Extract of Scholarly Conference Publication||Other Links:||http://www.srb.org.au/assets/SRBSociety/PastProceedings/SRB2006.pdf||Statistics to Oct 2018:||Visitors: 96
|Appears in Collections:||Conference Publication|
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