Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/16459
Title: Leptin is critical for successful implantation in mice
Contributor(s): Panwar, Shalini (author); McFarlane, James R (author)orcid 
Publication Date: 2006
Handle Link: https://hdl.handle.net/1959.11/16459
Abstract: Leptin, a 16kDa polypeptide, has long been known to have a role in reproduction as exogenous leptin administration can reverse the sterility of ob/ob mice which lack functional leptin. Leptin binds to cell surface receptors (Ob-R) and signals via STAT/JAK signal transduction pathway. This ligand receptor system is mandatory for embryonic implantation in rodents as withdrawl of leptin infusion in ob/ob females shortly after fertilization impairs implantation. Leptin and its receptors are expressed in human and mouse endometrium. Leptin has been immunolocalized in human and mouse preimplantation embryos and promotes mouse preimplantation embryo development through Ob-R signaling. The aim of our experiment was to study the impact of blocking leptin signaling in the mouse endometrium by giving intrauterine injections of leptin antiserum on day 1 and day 3 of pregnancy.
Publication Type: Conference Publication
Conference Name: 37th Annual Scientific Meeting of the Society for Reproductive Biology, Gold Coast, Australia, 20th - 23rd August, 2006
Conference Details: 37th Annual Scientific Meeting of the Society for Reproductive Biology, Gold Coast, Australia, 20th - 23rd August, 2006
Source of Publication: Society for Reproductive Biology Thirty-Seventh Annual Scientific Meeting Program and Abstracts, p. 81-81
Publisher: Society for Reproductive Biology
Place of Publication: online
Field of Research (FOR): 060603 Animal Physiology - Systems
Socio-Economic Outcome Codes: 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Category Description: E3 Extract of Scholarly Conference Publication
Other Links: http://www.srb.org.au/assets/SRBSociety/PastProceedings/SRB2006.pdf
Statistics to Oct 2018: Visitors: 96
Views: 127
Downloads: 0
Appears in Collections:Conference Publication

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

Page view(s)

18
checked on Dec 29, 2018
Google Media

Google ScholarTM

Check


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.