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Title: 'It's not about money, it's about my health': determinants of participation and adherence among women in an HIV-HSV2 prevention trial in Johannesburg, South Africa
Contributor(s): MacPhail, Catherine  (author)orcid ; Delany-Moretlwe, Sinead (author); Mayaud, Phillippe (author)
Publication Date: 2012
Open Access: Yes
DOI: 10.2147/PPA.S30759Open Access Link
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Abstract: High levels of adherence in clinical trials are essential for producing accurate intervention efficacy estimates. Adherence to clinical trial products and procedures is dependent on the motivations that drive participants. Data are presented to document reasons for trial participation and adherence to daily aciclovir for HSV-2 and HIV-1 genital shedding suppression among 300 HIV-1/HSV-2 seropositive women in South Africa. In-depth interviews after exit from the trial with 31 randomly selected women stratified by age and time since HIV diagnosis confirmed high levels of adherence measured during the trial. Main reasons for trial participation were related to seeking high-quality health care, which explains high levels of adherence in both study arms. Concerns that women would abuse reimbursements, fabricate data, and share or dump pills were not corroborated. Altruism is not a primary motivator in these settings where access to quality services is an issue. This study provides further evidence that good adherence of daily medication is possible in developing countries, particularly where study activities resonate with participants or fill an unmet need.
Publication Type: Journal Article
Source of Publication: Patient Preference and Adherence, v.6, p. 579-588
Publisher: Dove Press
Place of Publication: Aukland, New Zealand
ISSN: 1177-889X
Field of Research (FOR): 111712 Health Promotion
111717 Primary Health Care
Socio-Economic Outcome Codes: 920109 Infectious Diseases
920205 Health Education and Promotion
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Rural Medicine

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