Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/15940
Title: | Simulated Data for Genomic Selection and Genome-Wide Association Studies Using a Combination of Coalescent and Gene Drop Methods | Contributor(s): | Hickey, John (author); Gorjanc, Gregor (author) | Publication Date: | 2012 | Open Access: | Yes | DOI: | 10.1534/g3.111.001297 | Handle Link: | https://hdl.handle.net/1959.11/15940 | Abstract: | An approach is described for simulating data sequence, genotype, and phenotype data to study genomic selection and genome-wide association studies (GWAS). The simulation method, implemented in a software package called AlphaDrop, can be used to simulate genomic data and phenotypes with flexibility in terms of the historical population structure, recent pedigree structure, distribution of quantitative trait loci effects, and with sequence and single nucleotide polymorphism-phased alleles and genotypes. Ten replicates of a representative scenario used to study genomic selection in livestock were generated and have been made publically available. The simulated data sets were structured to encompass a spectrum of additive quantitative trait loci effect distributions, relationship structures, and single nucleotide polymorphism chip densities. | Publication Type: | Journal Article | Source of Publication: | G3: Genes, Genomes, Genetics, 2(4), p. 425-427 | Publisher: | Oxford University Press | Place of Publication: | United States of America | ISSN: | 2160-1836 | Fields of Research (FoR) 2008: | 070201 Animal Breeding 060408 Genomics 070301 Agro-ecosystem Function and Prediction |
Fields of Research (FoR) 2020: | 300305 Animal reproduction and breeding 310509 Genomics 300402 Agro-ecosystem function and prediction |
Socio-Economic Objective (SEO) 2008: | 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences | Socio-Economic Objective (SEO) 2020: | 280101 Expanding knowledge in the agricultural, food and veterinary sciences | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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