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Title: Investigation of the imaging quality of synchrotron-based phase-contrast mammographic tomography
Contributor(s): Gureyev, Timur  (author)orcid ; Mayo, S C (author); Tromba, G (author); Nesterets, Yakov  (author); Mohammadi, S (author); Lockie, D (author); Menk, R H (author); Pavlov, Konstantin M  (author)orcid ; Kitchen, M J (author); Zanconati, F (author); Dullin, C (author)
Publication Date: 2014
DOI: 10.1088/0022-3727/47/36/365401
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Abstract: We report the results of a systematic study of phase-contrast x-ray computed tomography in the propagation-based and analyser-based modes using specially designed phantoms and excised breast tissue samples. The study is aimed at the quantitative evaluation and subsequent optimization, with respect to detection of small tumours in breast tissue, of the effects of phase contrast and phase retrieval on key imaging parameters, such as spatial resolution, contrast-to-noise ratio, x-ray dose and a recently proposed 'intrinsic quality' characteristic which combines the image noise with the spatial resolution. We demonstrate that some of the methods evaluated in this work lead to substantial (more than 20-fold) improvement in the contrast-to-noise and intrinsic quality of the reconstructed tomographic images compared with conventional techniques, with the measured characteristics being in good agreement with the corresponding theoretical estimations. This improvement also corresponds to an approximately 400-fold reduction in the x-ray dose, compared with conventional absorption-based tomography, without a loss in the imaging quality. The results of this study confirm and quantify the significant potential benefits achievable in three-dimensional mammography using x-ray phase-contrast imaging and phase-retrieval techniques.
Publication Type: Journal Article
Source of Publication: Journal of Physics D: Applied Physics, 47(36), p. 1-18
Publisher: Institute of Physics Publishing Ltd
Place of Publication: United Kingdom
ISSN: 1361-6463
Field of Research (FOR): 020599 Optical Physics not elsewhere classified
Socio-Economic Objective (SEO): 861502 Medical Instruments
861503 Scientific Instruments
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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