Ferdosi, Mohammad

Kinghorn, Brian

Gondro, Cedric

Van Der Werf, Julius H

2014

Background: Identifying recombination events and the chromosomal segments that constitute a gamete is useful for a number of applications in genomic analyses. In livestock, genotypic data are commonly available for half-sib families. We propose a straightforward but computationally efficient method to use single nucleotide polymorphism marker genotypes on half-sibs to reconstruct the recombination and segregation events that occurred during meiosis in a sire to form the haplotypes observed in its offspring. These meiosis events determine a block structure in paternal haplotypes of the progeny and this can be used to phase the genotypes of individuals in single half-sib families, to impute haplotypes of the sire if they are not genotyped or to impute the paternal strand of the offspring's sequence based on sequence data of the sire.

Genetics Selection Evolution, v.46, p. 1-14

1297-9686

0999-193X

https://hdl.handle.net/1959.11/15546

BioMed Central Ltd

Detection of recombination events, haplotype reconstruction and imputation of sires using half-sib SNP genotypes

Journal Article

Publication