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|Title:||Detection of recombination events, haplotype reconstruction and imputation of sires using half-sib SNP genotypes||Contributor(s):||Ferdosi, Mohammad (author) ; Kinghorn, Brian (author); Gondro, Cedric (author) ; Van Der Werf, Julius H (author)||Publication Date:||2014||Open Access:||Yes||DOI:||10.1186/1297-9686-46-11||Handle Link:||https://hdl.handle.net/1959.11/15546||Abstract:||Background: Identifying recombination events and the chromosomal segments that constitute a gamete is useful for a number of applications in genomic analyses. In livestock, genotypic data are commonly available for half-sib families. We propose a straightforward but computationally efficient method to use single nucleotide polymorphism marker genotypes on half-sibs to reconstruct the recombination and segregation events that occurred during meiosis in a sire to form the haplotypes observed in its offspring. These meiosis events determine a block structure in paternal haplotypes of the progeny and this can be used to phase the genotypes of individuals in single half-sib families, to impute haplotypes of the sire if they are not genotyped or to impute the paternal strand of the offspring's sequence based on sequence data of the sire.||Publication Type:||Journal Article||Source of Publication:||Genetics Selection Evolution, v.46, p. 1-14||Publisher:||BioMed Central Ltd||Place of Publication:||London, United Kingdom||ISSN:||0999-193X
|Field of Research (FOR):||070202 Animal Growth and Development||Socio-Economic Outcome Codes:||970106 Expanding Knowledge in the Biological Sciences||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 493
|Appears in Collections:||Animal Genetics and Breeding Unit (AGBU)|
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