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Title: Genome-wide Detection of Signatures of Selection in Korean Hanwoo Cattle
Contributor(s): Porto-Neto, L R (author); Lee, S H (author); Sonstegard, T S (author); Van Tassell, C P (author); Lee, H K (author); Gibson, John  (author); Gondro, Cedric  (author)orcid 
Publication Date: 2014
DOI: 10.1111/age.12119
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Abstract: The Korean Hanwoo cattle have been intensively selected for production traits, especially high intramuscular fat content. It is believed that ancient crossings between different breeds contributed to forming the Hanwoo, but little is known about the genomic differences and similarities between other cattle breeds and the Hanwoo. In this work, cattle breeds were grouped by origin into four types and used for comparisons: the Europeans (represented by six breeds), zebu (Nelore), African taurine (N'Dama) and Hanwoo. All animals had genotypes for around 680 000 SNPs after quality control of genotypes. Average heterozygosity was lower in Nelore and N'Dama (0.22 and 0.21 respectively) than in Europeans (0.26–0.31, with Shorthorn as outlier at 0.24) and Hanwoo (0.29). Pairwise FST analyses demonstrated that Hanwoo are more related to European cattle than to Nelore, with N'Dama in an intermediate position. This finding was corroborated by principal components and unsupervised hierarchical clustering. Using genome-wide smoothed FST, 55 genomic regions potentially under positive selection in Hanwoo were identified. Among these, 29 were regions also detected in previous studies. Twenty-four regions were exclusive to Hanwoo, and a number of other regions were shared with one or two of the other groups. These regions overlap a number of genes that are related to immune, reproduction and fatty acid metabolism pathways. Further analyses are needed to better characterize the ancestry of the Hanwoo cattle and to define the genes responsible to the identified selection peaks.
Publication Type: Journal Article
Source of Publication: Animal Genetics, 45(2), p. 180-190
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: Chichester, United Kingdom
ISSN: 0268-9146
Field of Research (FOR): 060411 Population, Ecological and Evolutionary Genetics
Socio-Economic Outcome Codes: 970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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