Author(s) |
Lee, Seung-Hwan
Kim, Seung-Chang
Yang, Boh-Suk
Hong, Seong-Koo
Chai, Han-Ha
Cho, Soo-Hyun
Kim, Hyeong-Cheol
Lim, Dajeong
Choi, Bong-Hwan
Dang, Chang-Gwan
Sharma, Aditi
Gondro, Cedric
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Publication Date |
2014
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Abstract |
The objective of this study was to evaluate the effects of seven single nucleotide polymorphisms (SNPs) in Calpain 1 and Calpastatin genes previously associated with meat tenderness attributes in other cattle breeds in Korean Hanwoo cattle. The Hanwoo resource population was used to study association of 7 SNPs with beef tenderness, flavor, juiciness, intramuscular fat and shear force. In this association study, CAST:c.182A > G (+ 0.14, P = 0.04) and CAST:c.1985G > C (- 0.12, P = 0.02) had significant effects on juiciness, but no effects on other traits. In contrast, CAPN1:c.1589G > A was associated with meat tenderness (P = 0.01) and juiciness (P = 0.04). The CAPN1:c.1589G > A (Val530Ile) SNP marker displayed significant effect on the meat tenderness score which is strongly supported by molecular modeling of the CAPN1:c.1589G > A (Val530Ile) variant that inhibits CAST protein from binding more strongly than the wild-type protein, which may explain its effect on meat tenderness.
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Citation |
Meat Science, 96(4), p. 1501-1508
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ISSN |
1873-4138
0309-1740
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Link | |
Publisher |
Elsevier BV
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Title |
Mutations in calpastatin and µ-calpain are associated with meat tenderness, flavor and juiciness in Hanwoo (Korean cattle): Molecular modeling of the effects of substitutions on the calpastatin/µ-calpain complex
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Type of document |
Journal Article
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Entity Type |
Publication
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