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|Title:||Mutations in calpastatin and µ-calpain are associated with meat tenderness, flavor and juiciness in Hanwoo (Korean cattle): Molecular modeling of the effects of substitutions on the calpastatin/µ-calpain complex||Contributor(s):||Lee, Seung-Hwan (author); Kim, Seung-Chang (author); Yang, Boh-Suk (author); Hong, Seong-Koo (author); Chai, Han-Ha (author); Cho, Soo-Hyun (author); Kim, Hyeong-Cheol (author); Lim, Dajeong (author); Choi, Bong-Hwan (author); Dang, Chang-Gwan (author); Sharma, Aditi (author); Gondro, Cedric (author)||Publication Date:||2014||DOI:||10.1016/j.meatsci.2013.11.026||Handle Link:||https://hdl.handle.net/1959.11/15289||Abstract:||The objective of this study was to evaluate the effects of seven single nucleotide polymorphisms (SNPs) in Calpain 1 and Calpastatin genes previously associated with meat tenderness attributes in other cattle breeds in Korean Hanwoo cattle. The Hanwoo resource population was used to study association of 7 SNPs with beef tenderness, flavor, juiciness, intramuscular fat and shear force. In this association study, CAST:c.182A > G (+ 0.14, P = 0.04) and CAST:c.1985G > C (- 0.12, P = 0.02) had significant effects on juiciness, but no effects on other traits. In contrast, CAPN1:c.1589G > A was associated with meat tenderness (P = 0.01) and juiciness (P = 0.04). The CAPN1:c.1589G > A (Val530Ile) SNP marker displayed significant effect on the meat tenderness score which is strongly supported by molecular modeling of the CAPN1:c.1589G > A (Val530Ile) variant that inhibits CAST protein from binding more strongly than the wild-type protein, which may explain its effect on meat tenderness.||Publication Type:||Journal Article||Source of Publication:||Meat Science, 96(4), p. 1501-1508||Publisher:||Elsevier BV||Place of Publication:||Amsterdam, The Netherlands||ISSN:||1873-4138
|Field of Research (FOR):||070202 Animal Growth and Development||Socio-Economic Outcome Codes:||970106 Expanding Knowledge in the Biological Sciences||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 787
|Appears in Collections:||Journal Article|
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