Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/15289
Title: Mutations in calpastatin and µ-calpain are associated with meat tenderness, flavor and juiciness in Hanwoo (Korean cattle): Molecular modeling of the effects of substitutions on the calpastatin/µ-calpain complex
Contributor(s): Lee, Seung-Hwan (author); Kim, Seung-Chang (author); Yang, Boh-Suk (author); Hong, Seong-Koo (author); Chai, Han-Ha (author); Cho, Soo-Hyun (author); Kim, Hyeong-Cheol (author); Lim, Dajeong (author); Choi, Bong-Hwan (author); Dang, Chang-Gwan (author); Sharma, Aditi (author); Gondro, Cedric  (author)orcid 
Publication Date: 2014
DOI: 10.1016/j.meatsci.2013.11.026
Handle Link: https://hdl.handle.net/1959.11/15289
Abstract: The objective of this study was to evaluate the effects of seven single nucleotide polymorphisms (SNPs) in Calpain 1 and Calpastatin genes previously associated with meat tenderness attributes in other cattle breeds in Korean Hanwoo cattle. The Hanwoo resource population was used to study association of 7 SNPs with beef tenderness, flavor, juiciness, intramuscular fat and shear force. In this association study, CAST:c.182A > G (+ 0.14, P = 0.04) and CAST:c.1985G > C (- 0.12, P = 0.02) had significant effects on juiciness, but no effects on other traits. In contrast, CAPN1:c.1589G > A was associated with meat tenderness (P = 0.01) and juiciness (P = 0.04). The CAPN1:c.1589G > A (Val530Ile) SNP marker displayed significant effect on the meat tenderness score which is strongly supported by molecular modeling of the CAPN1:c.1589G > A (Val530Ile) variant that inhibits CAST protein from binding more strongly than the wild-type protein, which may explain its effect on meat tenderness.
Publication Type: Journal Article
Source of Publication: Meat Science, 96(4), p. 1501-1508
Publisher: Elsevier BV
Place of Publication: Netherlands
ISSN: 1873-4138
0309-1740
Fields of Research (FoR) 2008: 070202 Animal Growth and Development
Fields of Research (FoR) 2020: 300301 Animal growth and development
Socio-Economic Objective (SEO) 2008: 970106 Expanding Knowledge in the Biological Sciences
Socio-Economic Objective (SEO) 2020: 280102 Expanding knowledge in the biological sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

21
checked on Sep 7, 2024

Page view(s)

1,154
checked on Apr 7, 2024
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.