Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/14952
Title: Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: a systematic review and meta-analysis
Contributor(s): Haqq, Liza (author); McFarlane, James R (author)orcid ; Dieberg, Gudrun  (author)orcid ; Smart, Neil  (author)orcid 
Publication Date: 2014
Open Access: Yes
DOI: 10.1530/EC-14-0010Open Access Link
Handle Link: https://hdl.handle.net/1959.11/14952
Abstract: Polycystic ovarian syndrome (PCOS) affects 18-22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematically searching PubMed, CINAHL and the Cochrane Controlled Trials Registry (1966-April 30, 2013) systematically using key concepts of PCOS. Significant improvements were seen in women receiving lifestyle intervention vs usual care in follicle-stimulating hormone (FSH) levels, mean difference (MD) 0.39 IU/l (95% CI 0.09 to 0.70, P = 0.01), sex hormone-binding globulin (SHBG) levels,MD 2.37 nmol/l (95%CI 1.27 to 3.47, P = 0.0001), total testosterone levels, MD -0.13 nmol/l (95% CI -0.22 to -0.03, P = 0.008), androstenedione levels, MD -0.09 ng/dl (95% CI -0.15 to -0.03, P = 0.005), free androgen index (FAI) levels, MD -1.64 (95% CI -2.94 to -0.35, P = 0.01) and Ferriman-Gallwey (FG) score, MD -1.01 (95% CI -1.54 to -0.48, P = 0.0002). Significant improvements were also observed in women who received exercise-alone intervention vs usual care in FSH levels, MD 0.42 IU/l (95% CI 0.11 to 0.73, P = 0.009), SHBG levels, MD 3.42 nmol/l (95% CI 0.11 to 6.73, P = 0.04), total testosterone levels, MD -0.16 nmol/l (95% CI -0.29 to -0.04, P = 0.01), androstenedione levels, MD -0.09 ng/dl (95% CI -0.16 to -0.03, P = 0.004) and FG score, MD -1.13 (95% CI -1.88 to -0.38, PZ0.003). Our analyses suggest that lifestyle (diet and exercise) intervention improves levels of FSH, SHBG, total testosterone, androstenedione and FAI, and FG score in women with PCOS.
Publication Type: Journal Article
Source of Publication: Endocrine Connections, 3(1), p. 36-46
Publisher: BioScientifica Ltd
Place of Publication: United Kingdom
ISSN: 2049-3614
Field of Research (FOR): 110306 Endocrinology
111404 Reproduction
110602 Exercise Physiology
Socio-Economic Outcome Codes: 920114 Reproductive System and Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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