Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: a systematic review and meta-analysis

Title
Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: a systematic review and meta-analysis
Publication Date
2014
Author(s)
Haqq, Liza
McFarlane, James
( author )
OrcID: https://orcid.org/0000-0003-4429-5384
Email: jmcfarla@une.edu.au
UNE Id une-id:jmcfarla
Dieberg, Gudrun
( author )
OrcID: https://orcid.org/0000-0001-7191-182X
Email: gdieberg@une.edu.au
UNE Id une-id:gdieberg
Smart, Neil
( author )
OrcID: https://orcid.org/0000-0002-8290-6409
Email: nsmart2@une.edu.au
UNE Id une-id:nsmart2
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
BioScientifica Ltd
Place of publication
United Kingdom
DOI
10.1530/EC-14-0010
UNE publication id
une:15167
Abstract
Polycystic ovarian syndrome (PCOS) affects 18-22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematically searching PubMed, CINAHL and the Cochrane Controlled Trials Registry (1966-April 30, 2013) systematically using key concepts of PCOS. Significant improvements were seen in women receiving lifestyle intervention vs usual care in follicle-stimulating hormone (FSH) levels, mean difference (MD) 0.39 IU/l (95% CI 0.09 to 0.70, P = 0.01), sex hormone-binding globulin (SHBG) levels,MD 2.37 nmol/l (95%CI 1.27 to 3.47, P = 0.0001), total testosterone levels, MD -0.13 nmol/l (95% CI -0.22 to -0.03, P = 0.008), androstenedione levels, MD -0.09 ng/dl (95% CI -0.15 to -0.03, P = 0.005), free androgen index (FAI) levels, MD -1.64 (95% CI -2.94 to -0.35, P = 0.01) and Ferriman-Gallwey (FG) score, MD -1.01 (95% CI -1.54 to -0.48, P = 0.0002). Significant improvements were also observed in women who received exercise-alone intervention vs usual care in FSH levels, MD 0.42 IU/l (95% CI 0.11 to 0.73, P = 0.009), SHBG levels, MD 3.42 nmol/l (95% CI 0.11 to 6.73, P = 0.04), total testosterone levels, MD -0.16 nmol/l (95% CI -0.29 to -0.04, P = 0.01), androstenedione levels, MD -0.09 ng/dl (95% CI -0.16 to -0.03, P = 0.004) and FG score, MD -1.13 (95% CI -1.88 to -0.38, PZ0.003). Our analyses suggest that lifestyle (diet and exercise) intervention improves levels of FSH, SHBG, total testosterone, androstenedione and FAI, and FG score in women with PCOS.
Link
Citation
Endocrine Connections, 3(1), p. 36-46
ISSN
2049-3614
Start page
36
End page
46

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