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https://hdl.handle.net/1959.11/14940
Title: | Sugar alters the level of serum insulin and plasma glucose and the serum cortisol: DHEAS ratio in female migraine sufferers | Contributor(s): | Kokavec, Anna (author) ; Crebbin, Susan J (author) | Publication Date: | 2010 | DOI: | 10.1016/j.appet.2010.09.007 | Handle Link: | https://hdl.handle.net/1959.11/14940 | Abstract: | Early work has highlighted that a large percentage of migraineurs may have an altered glucidic methabolis due to carbohydrate-induced hyperinsulinism. The aim of this study was to assess the effect of sucrose on biomarkers of energy metabolism and utilization in migraineous females. A total of 16 participants (8 = Migraine, 8 = Non-migraine) at the mid-point of their menstrual cycle underwent a 15-h fast prior to ingesting 75 g sucrose dissolved in 175 g water. Blood sampling for the assessment of serum insulin, serum cortisol and serum dehydroepiandrosterone sulfate (DHEAS) and plasma glucose was conducted upon arrival at 09:00 h and then at regular 15-min intervals across a 150-min experimental period. The results showed a significant alteration in serum insulin and plasma glucose following sucrose ingestion in the migraine and non-migraine groups. In addition, significant group differences were observed in the level of serum insulin, serum DHEAS, and the cortisol:DHEAS ratio with migraine participants on average recording a higher sucrose-induced serum insulin level and lower DHEAS level and cortisol:DHEAS ratio when group data was compared. It was concluded that while sucrose consumption may potentiate serum insulin in migraineurs this does not result in the development of sucrose-induced hypoglycemia in migraine or non-migraine participants. | Publication Type: | Journal Article | Source of Publication: | Appetite, 55(3), p. 582-588 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 1095-8304 0195-6663 |
Fields of Research (FoR) 2008: | 111103 Nutritional Physiology 110102 Medical Biochemistry: Carbohydrates 110306 Endocrinology |
Socio-Economic Objective (SEO) 2008: | 920104 Diabetes 920411 Nutrition 920401 Behaviour and Health |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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