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https://hdl.handle.net/1959.11/14498
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DC Field | Value | Language |
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dc.contributor.author | Ebejer, Jane | en |
dc.contributor.author | Duffy, David L | en |
dc.contributor.author | Van Der Werf, Julius H | en |
dc.contributor.author | Wright, Margaret J | en |
dc.contributor.author | Montgomery, Grant W | en |
dc.contributor.author | Gillespie, Nathan A | en |
dc.contributor.author | Hickie, Ian B | en |
dc.contributor.author | Martin, Nicholas | en |
dc.contributor.author | Medland, Sarah | en |
dc.date.accessioned | 2014-04-02T13:10:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Twin Research and Human Genetics, 16(2), p. 560-574 | en |
dc.identifier.issn | 1839-2628 | en |
dc.identifier.issn | 1832-4274 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/14498 | - |
dc.description.abstract | Genome-wide association studies (GWAS) of attention-deficit/hyperactivity disorder (ADHD) offer the benefit of a hypothesis-free approach to measuring the quantitative effect of genetic variants on affection status. Generally the findings of GWAS relying on ADHD status have been non-significant, but the one study using quantitative measures of symptoms found SLC9A9 and SLC6A1 were associated with inattention and hyperactivity-impulsivity. Accordingly, we performed a GWAS using quantitative measures of each ADHD subtype measured with the Strengths and Weaknesses of ADHD and Normal Behaviour (SWAN) scale in two community-based samples. This scale captures the full range of attention and kinetic behavior; from high levels of attention and appropriate activity to the inattention and hyperactivity-impulsivity associated with ADHD within two community-based samples. Our discovery sample comprised 1,851 participants (mean age = 22.8 years [4.8]; 50.6% female), while our replication sample comprised 155 participants (mean age = 26.3 years [3.1]; 68.4% females). Age, sex, age × sex, and age² were included as covariates and the results from each sample were combined using meta-analysis, then analyzed with a gene-based test to estimate the combined effect of markers within genes. We compare our results with markers that have previously been found to have a strong association with ADHD symptoms. Neither the GWAS nor subsequent meta-analyses yielded genome-wide significant results; the strongest effect was observed at rs2110267 (4.62 × 10ˉ⁷) for symptoms of hyperactivity-impulsivity. The strongest effect in the gene-based test was for GPR139 on symptoms of inattention (6.40 × 10ˉ⁵). Replication of this study with larger samples will add to our understanding of the genetic etiology of ADHD. | en |
dc.language | en | en |
dc.publisher | Cambridge University Press | en |
dc.relation.ispartof | Twin Research and Human Genetics | en |
dc.title | Genome-Wide Association Study of Inattention and Hyperactivity-Impulsivity Measured as Quantitative Traits | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1017/thg.2013.12 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Quantitative Genetics (incl Disease and Trait Mapping Genetics) | en |
local.contributor.firstname | Jane | en |
local.contributor.firstname | David L | en |
local.contributor.firstname | Julius H | en |
local.contributor.firstname | Margaret J | en |
local.contributor.firstname | Grant W | en |
local.contributor.firstname | Nathan A | en |
local.contributor.firstname | Ian B | en |
local.contributor.firstname | Nicholas | en |
local.contributor.firstname | Sarah | en |
local.subject.for2008 | 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) | en |
local.subject.seo2008 | 920209 Mental Health Services | en |
local.profile.school | Psychology | en |
local.profile.school | Psychology | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | Psychology | en |
local.profile.school | Psychology | en |
local.profile.school | Psychology | en |
local.profile.school | Psychology | en |
local.profile.school | Rural Medical School | en |
local.profile.email | jebejer@une.edu.au | en |
local.profile.email | jvanderw@une.edu.au | en |
local.profile.email | nmarti24@une.edu.au | en |
local.profile.email | smedland@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20140311-100639 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 560 | en |
local.format.endpage | 574 | en |
local.identifier.scopusid | 84875983395 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 16 | en |
local.identifier.issue | 2 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Ebejer | en |
local.contributor.lastname | Duffy | en |
local.contributor.lastname | Van Der Werf | en |
local.contributor.lastname | Wright | en |
local.contributor.lastname | Montgomery | en |
local.contributor.lastname | Gillespie | en |
local.contributor.lastname | Hickie | en |
local.contributor.lastname | Martin | en |
local.contributor.lastname | Medland | en |
dc.identifier.staff | une-id:jebejer | en |
dc.identifier.staff | une-id:jvanderw | en |
dc.identifier.staff | une-id:nmarti24 | en |
dc.identifier.staff | une-id:smedland | en |
local.profile.orcid | 0000-0003-2512-1696 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:14713 | en |
local.identifier.handle | https://hdl.handle.net/1959.11/14498 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Genome-Wide Association Study of Inattention and Hyperactivity-Impulsivity Measured as Quantitative Traits | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Ebejer, Jane | en |
local.search.author | Duffy, David L | en |
local.search.author | Van Der Werf, Julius H | en |
local.search.author | Wright, Margaret J | en |
local.search.author | Montgomery, Grant W | en |
local.search.author | Gillespie, Nathan A | en |
local.search.author | Hickie, Ian B | en |
local.search.author | Martin, Nicholas | en |
local.search.author | Medland, Sarah | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000316817500007 | en |
local.year.published | 2013 | en |
local.subject.for2020 | 310506 Gene mapping | en |
local.subject.seo2020 | 200305 Mental health services | en |
Appears in Collections: | Journal Article |
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