Implications of Genetic Architecture on the Efficacy of Genomic Selection

Title
Implications of Genetic Architecture on the Efficacy of Genomic Selection
Publication Date
2013
Author(s)
Hely, Fiona
Clark, Sam A
( author )
OrcID: https://orcid.org/0000-0001-8605-1738
Email: sclark37@une.edu.au
UNE Id une-id:sclark37
Amer, Peter
Editor
Editor(s): Nicolas Lopez Villalobos
Type of document
Conference Publication
Language
en
Entity Type
Publication
Publisher
Association for the Advancement of Animal Breeding and Genetics (AAABG)
Place of publication
Armidale, Australia
UNE publication id
une:14690
Abstract
A simulation model is described which has been constructed to address the issue of how true underlying genomic architecture might impact on the efficacy of genomic selection. A current specific focus of the model is on how epistatic genetic architectures might impact on the added value expected from increasing the density of SNP markers. Results to date suggest that genomic selection has greater superiority over BLUP genetic prediction under the additive genetic architecture simulated relative to an epistatic architecture with similar heritability. While we expect marker density to improve accuracy under GBLUP with some additive genetic architectures, our simulation results suggest that this may not happen with comparable (in terms of narrow sense trait heritability) genetic architectures with epistatic gene action contributing to both additive and non-additive genetic variance.
Link
Citation
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.20, p. 229-232
ISSN
1328-3227
ISBN
9780473260569
Start page
229
End page
232

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