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Title: Implications of Genetic Architecture on the Efficacy of Genomic Selection
Contributor(s): Hely, Fiona (author); Clark, Sam A  (author)orcid ; Amer, Peter (author)
Publication Date: 2013
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Abstract: A simulation model is described which has been constructed to address the issue of how true underlying genomic architecture might impact on the efficacy of genomic selection. A current specific focus of the model is on how epistatic genetic architectures might impact on the added value expected from increasing the density of SNP markers. Results to date suggest that genomic selection has greater superiority over BLUP genetic prediction under the additive genetic architecture simulated relative to an epistatic architecture with similar heritability. While we expect marker density to improve accuracy under GBLUP with some additive genetic architectures, our simulation results suggest that this may not happen with comparable (in terms of narrow sense trait heritability) genetic architectures with epistatic gene action contributing to both additive and non-additive genetic variance.
Publication Type: Conference Publication
Conference Details: 20th Conference of the Association for the Advancement of Animal Breeding and Genetics: Translating Science into Action, Napier, New Zealand, 20th - 23rd October, 2013
Source of Publication: Proceedings of the Twentieth Conference of the Association for the Advancement of Animal Breeding and Genetics, p. 229-232
Publisher: AAABG: Association for the Advancement of Animal Breeding and Genetics
Place of Publication: Palmerston North, New Zealand
Field of Research (FOR): 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
Socio-Economic Objective (SEO): 830310 Sheep - Meat
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
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Series Name: Proceedings of the AAABG ... Conference
Series Number : 20
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