Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/14264
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dc.contributor.authorSmart, Neilen
dc.contributor.authorMcFarlane, James Ren
dc.contributor.authorCornelissen, Veroniqueen
dc.date.accessioned2014-03-13T14:36:00Z
dc.date.issued2013en
dc.identifier.citationOpen Journal of Nephrology, 3(1), p. 25-36en
dc.identifier.issn2164-2869en
dc.identifier.issn2164-2842en
dc.identifier.urihttps://hdl.handle.net/1959.11/14264en
dc.description.abstractBackground: Patients undergoing dialysis have high mortality rates and a unique risk factor profile. Some improvements elicited by exercise training have been shown in dialysis populations, here we aimed to further explore the benefits of exercise. As well as changes in physical fitness we quantified cardiac function, depression, serum biochemistry, dialysis adequacy and energy intake following exercise training in people with chronic kidney disease (CKD) undertaking dialysis. Methods: A systematic literature search was completed in December 2012 identifying randomized, controlled trials of exercise training studies in haemodialysis (HD) patients. A subsequent meta-analysis was conducted. Results: Twenty four studies were included, totalling 879 patients. Exercise training produced significant improvements in physical fitness: peak VO₂ 5.03 mlO₂·kg⁻¹·min⁻¹ (95% CI 3.73, 6.33, p < 0.0001), Knee extensor strength 2.99 kg (95% CI 0.46, 5.52, p = 0.02) and 6 minute walk distance 60.7 metres (95% CI 18.9, 103, p = 0.004). Significant increases in energy intake MD 238 Kcal·day⁻¹ (95% CI 94, 383, p = 0.001), serum Interleukin-6 MD-0.58 pg·ml⁻¹ (95% CI-1.01, -0.15, p = 0.008) and C-reactive protein MD 0.92 mg/L⁻¹ (95% CI 0.29, 1.56, p = 0.004), but not Albumin or BMI, were reported. Improved Beck Depression scores were reported MD-6.9 (95% CI-9.7,-4.1, p < 0.00001). Dialysis adequacy was reduced MD-0.23 (95% CI -0.29, -0.17, p < 0.00001), while serum potassium was higher MD 0.14 mmol·L⁻¹ (95% CI 0.01, 0.27, p = 0.04). Moreover exercise training appeared safe, with no direct exercise-associated deaths in over 30,000 patient-hours. Conclusions: Our pooled analyses confirmed improvements in physical fitness following exercise training and suggested additional improvements in dialysis efficiency (kt/v), serum potassium, inflammation and depression in HD patients.en
dc.languageenen
dc.publisherScientific Research Publishing Incen
dc.relation.ispartofOpen Journal of Nephrologyen
dc.titleThe Effect of Exercise Therapy on Physical Function, Biochemistry and Dialysis Adequacy in Haemodialysis Patients: A Systematic Review and Meta-Analysisen
dc.typeJournal Articleen
dc.identifier.doi10.4236/ojneph.2013.31005en
dcterms.accessRightsGolden
dc.subject.keywordsExercise Physiologyen
local.contributor.firstnameNeilen
local.contributor.firstnameJames Ren
local.contributor.firstnameVeroniqueen
local.subject.for2008110602 Exercise Physiologyen
local.subject.seo2008920119 Urogenital System and Disordersen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolHuman Biology and Physiologyen
local.profile.emailnsmart2@une.edu.auen
local.profile.emailjmcfarla@une.edu.auen
local.profile.emailvcorneli@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20140122-132217en
local.publisher.placeUnited States of Americaen
local.format.startpage25en
local.format.endpage36en
local.peerreviewedYesen
local.identifier.volume3en
local.identifier.issue1en
local.title.subtitleA Systematic Review and Meta-Analysisen
local.access.fulltextYesen
local.contributor.lastnameSmarten
local.contributor.lastnameMcFarlaneen
local.contributor.lastnameCornelissenen
dc.identifier.staffune-id:nsmart2en
dc.identifier.staffune-id:jmcfarlaen
dc.identifier.staffune-id:vcornelien
local.profile.orcid0000-0002-8290-6409en
local.profile.orcid0000-0003-4429-5384en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:14479en
local.identifier.handlehttps://hdl.handle.net/1959.11/14264en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleThe Effect of Exercise Therapy on Physical Function, Biochemistry and Dialysis Adequacy in Haemodialysis Patientsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 266<br />Views: 277<br />Downloads: 0en
local.search.authorSmart, Neilen
local.search.authorMcFarlane, James Ren
local.search.authorCornelissen, Veroniqueen
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