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Title: A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content
Contributor(s): Zhang, Hui (author); Wang, Shou-Zhi (author); Li, Hui (author); Wang, Zhi-Peng (author); Da, Yang (author); Wang, Ning (author); Hu, Xiao-Xiang (author); Zhang, Yuan-Dan  (author); Wang, Yu-Xiang (author); Leng, Li (author); Tang, Zhi-Quan (author)
Publication Date: 2012
Open Access: Yes
DOI: 10.1186/1471-2164-13-704Open Access Link
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Abstract: Background: Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF. Results: A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens. Conclusions: We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.
Publication Type: Journal Article
Source of Publication: BMC Genomics, v.13, p. 1-16
Publisher: BioMed Central Ltd
Place of Publication: United Kingdom
ISSN: 1471-2164
Field of Research (FOR): 070201 Animal Breeding
Socio-Economic Outcome Codes: 830309 Poultry
860103 Carcass Meat (incl. Fish and Seafood)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
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