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https://hdl.handle.net/1959.11/14055
Title: | Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications | Contributor(s): | Giallauria, Francesco (author); Vigorito, Carlo (author); Ferrara, Nicola (author); Ferrucci, Luigi (author) | Publication Date: | 2013 | DOI: | 10.1007/s13670-013-0063-4 | Handle Link: | https://hdl.handle.net/1959.11/14055 | Abstract: | Vascular calcification, a hallmark of aging, is accelerated in patients with hypertension, diabetes, and chronic kidney disease. It may be viewed as the result of disturbances of the complex and subtle balance between inhibitors and promoters, acting at both the systemic and local levels. Ethnic differences in certain components of the atherosclerosis process were identified previously; however, recent evidence suggests that atherosclerosis is not a modern disease and may be viewed as an inherent component of human aging, unrelated to any specific diet or lifestyle. In this review, we highlight the mechanisms governing vascular calcification and its association with aging. By understanding the pathways involved in these processes, novel drug targets may be proposed in an effort to reduce the effects of vascular calcification as a risk factor. | Publication Type: | Journal Article | Source of Publication: | Current Translational Geriatrics and Experimental Gerontology Reports, 2(4), p. 255-267 | Publisher: | Springer | Place of Publication: | United States of America | ISSN: | 2162-4941 | Fields of Research (FoR) 2008: | 110308 Geriatrics and Gerontology 110201 Cardiology (incl Cardiovascular Diseases) |
Fields of Research (FoR) 2020: | 320210 Geriatrics and gerontology 320101 Cardiology (incl. cardiovascular diseases) |
Socio-Economic Objective (SEO) 2008: | 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified 920103 Cardiovascular System and Diseases |
Socio-Economic Objective (SEO) 2020: | 200199 Clinical health not elsewhere classified 200101 Diagnosis of human diseases and conditions |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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