Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/14055
Title: Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications
Contributor(s): Giallauria, Francesco  (author); Vigorito, Carlo (author); Ferrara, Nicola (author); Ferrucci, Luigi (author)
Publication Date: 2013
DOI: 10.1007/s13670-013-0063-4
Handle Link: https://hdl.handle.net/1959.11/14055
Abstract: Vascular calcification, a hallmark of aging, is accelerated in patients with hypertension, diabetes, and chronic kidney disease. It may be viewed as the result of disturbances of the complex and subtle balance between inhibitors and promoters, acting at both the systemic and local levels. Ethnic differences in certain components of the atherosclerosis process were identified previously; however, recent evidence suggests that atherosclerosis is not a modern disease and may be viewed as an inherent component of human aging, unrelated to any specific diet or lifestyle. In this review, we highlight the mechanisms governing vascular calcification and its association with aging. By understanding the pathways involved in these processes, novel drug targets may be proposed in an effort to reduce the effects of vascular calcification as a risk factor.
Publication Type: Journal Article
Source of Publication: Current Translational Geriatrics and Experimental Gerontology Reports, 2(4), p. 255-267
Publisher: Springer
Place of Publication: United States of America
ISSN: 2162-4941
Fields of Research (FoR) 2008: 110308 Geriatrics and Gerontology
110201 Cardiology (incl Cardiovascular Diseases)
Fields of Research (FoR) 2020: 320210 Geriatrics and gerontology
320101 Cardiology (incl. cardiovascular diseases)
Socio-Economic Objective (SEO) 2008: 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
920103 Cardiovascular System and Diseases
Socio-Economic Objective (SEO) 2020: 200199 Clinical health not elsewhere classified
200101 Diagnosis of human diseases and conditions
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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