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https://hdl.handle.net/1959.11/13964
Title: | Identification of Recently Selected Mutations Driven by Artificial Selection in Hanwoo (Korean Cattle) | Contributor(s): | Lim, Dajeong (author); Gondro, Cedric (author) ; Park, Hye Sun (author); Cho, Yong Min (author); Chai, Han Ha (author); Seong, Hwan Hoo (author); Yang, Bo Suk (author); Hong, Seong Koo (author); Chang, Won Kyung (author); Lee, Seung Hwan (author) | Publication Date: | 2013 | Open Access: | Yes | DOI: | 10.5713/ajas.2012.12456 | Handle Link: | https://hdl.handle.net/1959.11/13964 | Abstract: | Hanwoo have been subjected over the last seventy years to intensive artificial selection with the aim of improving meat production traits such as marbling and carcass weight. In this study, we performed a signature of selection analysis to identify recent positive selected regions driven by a long-term artificial selection process called a breeding program using whole genome SNP data. In order to investigate homozygous regions across the genome, we estimated iES (integrated Extended Haplotype Homozygosity SNP) for the each SNPs. As a result, we identified two highly homozygous regions that seem to be strong and/or recent positive selection. Five genes (DPH5, OLFM3, S1PR1, LRRN1 and CRBN) were included in this region. To go further in the interpretation of the observed signatures of selection, we subsequently concentrated on the annotation of differentiated genes defined according to the iES value of SNPs localized close or within them. We also described the detection of the adaptive evolution at the molecular level for the genes of interest. As a result, this analysis also led to the identification of OLFM3 as having a strong signal of selection in bovine lineage. The results of this study indicate that artificial selection which might have targeted most of these genes was mainly oriented towards improvement of meat production. | Publication Type: | Journal Article | Source of Publication: | Asian-Australasian Journal of Animal Sciences, 26(5), p. 603-608 | Publisher: | Asian-Australasian Association of Animal Production Societies | Place of Publication: | Republic of Korea | ISSN: | 1976-5517 1011-2367 |
Fields of Research (FoR) 2008: | 060411 Population, Ecological and Evolutionary Genetics | Fields of Research (FoR) 2020: | 310599 Genetics not elsewhere classified | Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences | Socio-Economic Objective (SEO) 2020: | 280102 Expanding knowledge in the biological sciences | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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