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Title: Effect of Accuracy of QTL Parameters Estimation on Genetic Response to Genotype Assisted Selection in Farm Animals
Contributor(s): Moghaddar, Nasir (author); Van Der Werf, Julius H (author)orcid 
Publication Date: 2007
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Abstract: Selection on estimated QTL effects could be detrimental if the estimated effect is inaccurate. In this study, effect of inaccurate estimation of QTL effect on Genotype Assisted selection (GAS) was investigated. We assumed various estimated QTL effects and various associated standard errors, and further, varied heritability and initial QTL allele frequency. True QTL effects were sampled from the posterior of the likelihood of QTL-hat and a prior gamma distribution of QTL effects. The ratio of GAS response and non-GAS (mass selection) response over repeated samples for a true QTL effect were averaged. The results showed that the GAS/non-GAS ratios was >1.267 for QTL effects of 0.5 of one phenotypic standard deviation (σp) when the SE was < 0.02 and heritability 0.2. For an effect of 0.4 and 0.3, the SE should be less than 0.141 and 0.117, respectively, before MAS becomes profitable. Assuming no error of QTL effect would give 10.61%, 5.34% and 2.31% more gain for effects of 0.4, 0.3 and 0.2σp respectively. However, accounting for a standard error of 0.05 would give estimated benefits of MAS over non-GAS of 8.89%, 4.35% and 1.56% respectively.
Publication Type: Conference Publication
Conference Name: 3rd International Conference on Quantitative Genetics (ICQG3), Hangzhou, China, 19th - 24th August, 2007
Source of Publication: 3rd International Conference on Quantitative Genetics Abstracts
Publisher: ICQG
Place of Publication: online
Field of Research (FOR): 070201 Animal Breeding
HERDC Category Description: E3 Extract of Scholarly Conference Publication
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