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Title: Differences in neurobiological pathways of four "clinical content" subtypes of depression
Contributor(s): Sharpley, Christopher  (author)orcid ; Bitsika, Vicki  (author)
Publication Date: 2013
DOI: 10.1016/j.bbr.2013.08.030
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Abstract: Although often considered as a mental disorder, depression is best described as a behavioral neurobiological phenomenon. In addition, although usually reported as a unitary diagnosis, major depressive episode is composed of a range of different symptoms that can occur in nearly 1500 possible combinations to fulfill the required diagnostic criterion. To investigate and describe the underlying behavioral and neurobiological substrates of these symptoms, they were clustered into "clinical content" subtypes of depression according to their predominant common behavioral characteristics. These subtypes were then found to possess different neurobiological pathways that argue for different treatment approaches.
Publication Type: Journal Article
Source of Publication: Behavioural Brain Research, v.256, p. 368-376
Publisher: Elsevier BV
Place of Publication: The Netherlands
ISSN: 1872-7549
Field of Research (FOR): 110319 Psychiatry (incl Psychotherapy)
Socio-Economic Outcome Codes: 920111 Nervous System and Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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