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|Title:||Differing Models of Association between Childhood Events, Recent Life Stressors, Psychological Resilience and Depression across Three Alleles of the Serotonin Transporter 5-HTTLPR||Contributor(s):||Sharpley, Christopher (author) ; Athiappan Palanisamy, Suresh K (author); McFarlane, James R (author)||Publication Date:||2013||Handle Link:||https://hdl.handle.net/1959.11/13304||Abstract:||Background: Although some previous research has implicated the short form (ss) of the serotonin transporter 5-HTTLPR gene in the association between distal and proximal environmental stress and depression, over 38% of studies included in a recent meta-analysis failed to support that finding. Another variant of the 5-HTTLPT, the sl, has been relatively under-examined and may explain the inconsistency of the ss/ll dichotomy. In addition, a potential 'buffer' variable between proximal and distal stress and depression - psychological resilience - may interact with the forms of the 5-HTTLPR. This study investigated the ways the three forms of the 5-HTTLPR interacted with distal and proximal stress, and psychological resilience, to predict depression. Methods: A volunteer community sample of 65 female and 55 male volunteers completed background, childhood stress (Adverse Childhood Events-ACE), recent stress (RLS), depression (Zung Self-Rating Depression Scale-ZSDS) and resilience (Connors-Davidson Resilience Scale-CD-RISC) questionnaires, plus gave a sample for genotyping to determine presence of ss, sl, or ll variants of the 5-HTTLPR. Results: Comparison of the regression equations for each 5-HTTLPR variant showed that the combination of ACE, RLS and CD-RISC significantly predicted ZSDS scores for the sl variant; ACE, CD-RISC (but not RLS) significantly predicted ZSDS for the ll variant; and none of these significantly predicted ZSDS for the ss variant. Conclusions: Previous inconsistent findings regarding the differences in the stress-depression interaction for the ss and ll may be explained by the more complex interaction effects of the sl variant with distal and recent stressors and psychological resilience.||Publication Type:||Journal Article||Source of Publication:||German Journal of Psychiatry, 16(3), p. 103-111||Publisher:||Georg-August-Universitaet Goettingen [University of Goettingen]||Place of Publication:||Goettingen, Germany||ISSN:||1433-1055||Field of Research (FOR):||110319 Psychiatry (incl Psychotherapy)||Socio-Economic Outcome Codes:||920111 Nervous System and Disorders||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Other Links:||http://www.gjpsy.uni-goettingen.de/gjp-article-sharpley-differing.pdf||Statistics to Oct 2018:||Visitors: 168
|Appears in Collections:||Journal Article|
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