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Title: Application of Testis Germ Cell Transplantation in Breeding Systems of Food Producing Species: A Review
Contributor(s): Herrid, Muren  (author); McFarlane, James R  (author)orcid 
Publication Date: 2013
DOI: 10.1080/10495398.2013.785431
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Fields of Research (FoR) 2008: 070206 Animal Reproduction
111404 Reproduction
Fields of Research (FoR) 2020: 300305 Animal reproduction and breeding
321503 Reproduction
Socio-Economic Objective (SEO) 2008: 830399 Livestock Raising not elsewhere classified
920114 Reproductive System and Disorders
Socio-Economic Objective (SEO) 2020: 100407 Insects
200101 Diagnosis of human diseases and conditions
Abstract: A major benefit of advanced reproduction technologies (ART) in animal breeding is the ability to produce more progeny per individual parent. This is particularly useful with animals of high genetic merit. Testis germ cell transplantation (TGCT) is emerging as a novel reproductive technology with application in animal breeding systems, including the potential for use as an alternative to artificial insemination (AI), an alternative to transgenesis, part of an approach to reducing generation intervals, or an approach toward development of interspecies hybrids. There is one major difference in TGCT between rodents and some other species associated with immunotolerance in heterologous transplantation. In particular, livestock and aquatic species do not require an immunesuppression procedure to allow donor cell survival in recipient testis. Testicular stem cells from a genetically elite individual transplanted into others can develop and produce a surrogate male - an animal that produces the functional sperm of the original individual. Spermatozoa produced from testis stem cells are the only cells in the body of males that can transmit genetic information to the offspring. The isolation and genetic manipulation of testis stem cells prior to transplantation has been shown to create transgenic animals. However, the current success rate of the transplantation procedure in livestock and aquatic species is low, with a corresponding small proportion of donor spermatozoa in the recipient's semen. The propagation of donor cells in culture and preparation of recipient animals are the two main factors that limit the commercial application of this technique. The current paper reviews and compares recent progress and examines the difficulties of TGCT in both livestock and aquatic species, thereby providing new insights into the application of TGCT in food producing animals.
Publication Type: Journal Article
Source of Publication: Animal Biotechnology, 24(4), p. 293-306
Publisher: Taylor & Francis Inc
Place of Publication: United States of America
ISSN: 1532-2378
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science

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