Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/13076
Title: | Genomic evaluations using similarity between haplotypes | Contributor(s): | Hickey, John (author); Kinghorn, Brian (author); Tier, Bruce (author); Clark, Sam A (author)![]() ![]() |
Publication Date: | 2013 | DOI: | 10.1111/jbg.12020 | Handle Link: | https://hdl.handle.net/1959.11/13076 | Abstract: | Long-range phasing and haplotype library imputation methodologies are accurate and efficient methods to provide haplotype information that could be used in prediction of breeding value or phenotype. Modelling long haplotypes as independent effects in genomic prediction would be inefficient due to the many effects that need to be estimated and phasing errors, even if relatively low in frequency, exacerbate this problem. One approach to overcome this is to use similarity between haplotypes to model covariance of genomic effects by region or of animal breeding values. We developed a simple method to do this and tested impact on genomic prediction by simulation. Results show that the diagonal and off-diagonal elements of a genomic relationship matrix constructed using the haplotype similarity method had higher correlations with the true relationship between pairs of individuals than genomic relationship matrices built using unphased genotypes or assumed unrelated haplotypes. However, the prediction accuracy of such haplotype-based prediction methods was not higher than those based on unphased genotype information. | Publication Type: | Journal Article | Grant Details: | ARC/LP100100880 | Source of Publication: | Journal of Animal Breeding and Genetics, 130(4), p. 259-269 | Publisher: | Wiley-Blackwell Verlag GmbH | Place of Publication: | Germany | ISSN: | 1439-0388 0931-2668 |
Fields of Research (FoR) 2008: | 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) | Fields of Research (FoR) 2020: | 310506 Gene mapping | Socio-Economic Objective (SEO) 2008: | 830301 Beef Cattle 830302 Dairy Cattle |
Socio-Economic Objective (SEO) 2020: | 100401 Beef cattle 100402 Dairy cattle |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
---|---|
Appears in Collections: | Animal Genetics and Breeding Unit (AGBU) Journal Article |
Files in This Item:
File | Description | Size | Format |
---|
SCOPUSTM
Citations
22
checked on Aug 17, 2024
Page view(s)
2,638
checked on Aug 11, 2024
Download(s)
2
checked on Aug 11, 2024
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.