Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/12915
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dc.contributor.authorPurushothaman, Dharmaen
dc.contributor.authorBrown, Wendyen
dc.contributor.authorWu, Shubiaoen
dc.contributor.authorVanselow, Barbaraen
dc.date.accessioned2013-07-08T15:04:00Z-
dc.date.issued2012-
dc.identifier.citationAustralasian Medical Journal, 5(12), p. 695-695en
dc.identifier.issn1836-1935en
dc.identifier.urihttps://hdl.handle.net/1959.11/12915-
dc.description.abstractBackground: Previous studies have demonstrated that DHA n-3 FA can reduce obesity by inhibiting adipocyte differentiation. Objective: To investigate the potential of a DHA rich supplement (fish oil; FO) over non DHA (sunflower oil; SF) to reduce weight gain in dogs, when the animals were fed increased dietary energy intakes above maintenance levels (iso-caloric in both groups). The transcriptional, metabolic and phenotypic responses in two dog breeds were assessed. Design: Six beagles and greyhounds were divided equally into two treatment groups (FO and SF). During four weeks, energy intake was increased 20-80% above maintenance level achieved by feeding basal diet (kibble), coconut fat and supplement (FO or SF). Changes to body weight gain (BWG), apparent nutrient digestibility (Dry Matter, Fat, and Gross Energy), red blood cell (RBC) FA levels, White Blood Cell (WBC) inflammatory gene expression levels (HSP90, HSP70 and IL1β) were measured twice: at days 0 and 28. A paired t-test was used to determine significance between time periods, treatments or breeds. Outcomes: BWG in beagles fed FO were significantly higher (P<0.05) than those fed SF. No significant differences in BWG in greyhounds or between breeds were shown. Differences were not seen in apparent nutrient digestibility. HSP90 gene expression was up-regulated in the beagles fed FO (P<0.05), while HSP70 gene down-regulated for both breeds fed SF (P<0.05). A significant breed difference was observed for HSP70 fed SF (P<0.05). RBC EPA levels significantly increased in both breeds fed FO (P<0.05) with no significant difference in DHA levels. Only beagles fed SF showed significant increase in LA, AA (P<0.05). Both breeds fed SF showed significant decrease in GLA (P<0.05). Significant breed differences (P<0.05) were found in RBC FA levels of EPA (FO), LA, GLA and AA (SF). Conclusion: Results from the four weeks trial do not support the potential of DHA n-3 FA to reduce BWG. However, within the same time frame, WBC inflammatory gene expression and RBC FA levels showed differences between treatments and breeds. Therefore breed differences warrant further investigation and future studies should be designed for extended periods with larger datasets.en
dc.languageenen
dc.publisherAustralasian Medical Journal Pty Ltden
dc.relation.ispartofAustralasian Medical Journalen
dc.titleEvaluating changes in body weight gain, nutrient digestibility, inflammatory gene expression and RBC FA following DHA- rich fish oil supplementation in two dog breedsen
dc.typeJournal Articleen
dc.subject.keywordsAnimal Growth and Developmenten
dc.subject.keywordsAnimal Nutritionen
local.contributor.firstnameDharmaen
local.contributor.firstnameWendyen
local.contributor.firstnameShubiaoen
local.contributor.firstnameBarbaraen
local.subject.for2008070202 Animal Growth and Developmenten
local.subject.for2008070204 Animal Nutritionen
local.subject.seo2008839901 Animal Welfareen
local.subject.seo2008839999 Animal Production and Animal Primary Products not elsewhere classifieden
local.profile.schoolRSA School Establishment Positionsen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emaildpurusho@une.edu.auen
local.profile.emailwbrown@une.edu.auen
local.profile.emailswu3@une.edu.auen
local.profile.emailbvansel2@une.edu.auen
local.output.categoryC4en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20130416-16140en
local.publisher.placeAustraliaen
local.format.startpage695en
local.format.endpage695en
local.identifier.volume5en
local.identifier.issue12en
local.contributor.lastnamePurushothamanen
local.contributor.lastnameBrownen
local.contributor.lastnameWuen
local.contributor.lastnameVanselowen
dc.identifier.staffune-id:dpurushoen
dc.identifier.staffune-id:wbrownen
dc.identifier.staffune-id:swu3en
dc.identifier.staffune-id:bvansel2en
local.profile.orcid0000-0002-5309-3381en
local.profile.orcid0000-0002-1790-6015en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:13123en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleEvaluating changes in body weight gain, nutrient digestibility, inflammatory gene expression and RBC FA following DHA- rich fish oil supplementation in two dog breedsen
local.output.categorydescriptionC4 Letter of Noteen
local.search.authorPurushothaman, Dharmaen
local.search.authorBrown, Wendyen
local.search.authorWu, Shubiaoen
local.search.authorVanselow, Barbaraen
local.uneassociationUnknownen
local.year.published2012en
local.subject.for2020300301 Animal growth and developmenten
local.subject.for2020300303 Animal nutritionen
local.subject.seo2020109902 Animal welfareen
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School of Environmental and Rural Science
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