Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/12709
Title: Characterization and Bioactivity of Essential Oils from 'Geijera parviflora' (Rutaceae): A Native Bush Medicine from Australia
Contributor(s): Sadgrove, Nicholas (author); Jones, Graham L (author)orcid 
Publication Date: 2013
Handle Link: https://hdl.handle.net/1959.11/12709
Abstract: Essential oil was hydrodistilled from the Australian Wilga, botanically named 'G. parviflora' Lindl., (Rutaceae). Fresh and aged essential oils were characterized using GC-MS, quantified using GC-FID and screened for bacterial inhibition qualitatively using disc diffusion and quantitatively using micro-titer plate broth dilution. To identify components responsible for bacterial inhibition, TLC-bioautography was used. Free radical scavenging capacity was determined using diphenylpicrylhydrazyl in methanol, and solvent extracts of the leaves using light petroleum, acetone and water were screened for qualitative pharmacological properties, as well as extracts produced by smoking the leaves and channeling into a condenser. Results showed that all essential oils extracted here conform broadly in composition to a previous identified chemotype with α-pinene, camphene and sabinene as the main constituents. As the essential oils age, polymerization of peroxide intermediates produced epoxycaryophyllene in at least one of our samples. The fresh oil showed only a modest level of antibacterial activity, but this became pronounced as the oil aged in storage, which resulted from a chemical change in the oil during years of storage at 4°C. Bioautography revealed that the antimicrobial capacity of the fresh oil may be attributed to its less abundant constituents, mainly α-terpineol, terpinen-4-ol, spathulenol, 1,8-cineole and camphor. The solvent extracts of the leaves revealed the presence of saponins, triterpenoids and alkaloids. The last two of these were also present in the smoke extract.
Publication Type: Journal Article
Source of Publication: Natural Product Communications, 8(6), p. 747-751
Publisher: Natural Product Inc
Place of Publication: United States of America
ISSN: 1555-9475
1934-578X
Field of Research (FOR): 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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